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Tuberin antibody (Ser1798)

TSC2 Reactivity: Human IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN358936
  • Target See all Tuberin (TSC2) Antibodies
    Tuberin (TSC2) (Tuberous Sclerosis 2 (TSC2))
    Binding Specificity
    • 29
    • 22
    • 20
    • 19
    • 16
    • 16
    • 15
    • 15
    • 15
    • 13
    • 12
    • 11
    • 11
    • 10
    • 8
    • 8
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 5
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Ser1798
    Reactivity
    • 291
    • 195
    • 124
    • 8
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 383
    • 12
    Rabbit
    Clonality
    • 374
    • 21
    Polyclonal
    Conjugate
    • 144
    • 35
    • 33
    • 31
    • 24
    • 24
    • 11
    • 11
    • 11
    • 11
    • 10
    • 10
    • 7
    • 7
    • 7
    • 7
    • 7
    • 1
    • 1
    • 1
    • 1
    • 1
    This Tuberin antibody is un-conjugated
    Application
    • 212
    • 184
    • 125
    • 81
    • 80
    • 66
    • 36
    • 33
    • 20
    • 12
    • 9
    • 6
    • 6
    • 4
    • 2
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificity
    This antibody reacts to Tuberin (TSC2).
    Purification
    Protein A column, followed by peptide affinity purification
    Immunogen
    This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide corresponding to amino acid residues surrounding S1798 of human TSC2.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product TSC2 Primary Antibody
  • Application Notes
    ELISA: 1/1,000. Immunohistochemistry: 1/10 - 1/50.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.25 mg/mL
    Buffer
    PBS with 0.09 % (W/V) sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • Target
    Tuberin (TSC2) (Tuberous Sclerosis 2 (TSC2))
    Alternative Name
    Tuberin / TSC2 (TSC2 Products)
    Synonyms
    TSC2 antibody, fc16b02 antibody, tuberin antibody, wu:fc16b02 antibody, LAM antibody, TSC4 antibody, Nafld antibody, Tcs2 antibody, Rc antibody, TSC complex subunit 2 antibody, tuberin antibody, hypothetical protein antibody, tuberous sclerosis 2 antibody, TSC2 antibody, LOC5569538 antibody, tsc2 antibody, PGTG_00159 antibody, Tsc2 antibody
    Background
    Mutations in TSC2 lead to tuberous sclerosis complex. This protein is believed to be a tumor suppressor and is able to specifically stimulate the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. TSC2 associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. It may have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking.Synonyms: TSC4, Tuberous sclerosis 2 protein
    Gene ID
    7249, 9606
    UniProt
    P49815
    Pathways
    RTK Signaling, AMPK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Cell Size, Tube Formation, Protein targeting to Nucleus
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