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Deoxyguanosine Kinase antibody (C-Term)

DGUOK Reactivity: Human, Mouse WB, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN359186
  • Target See all Deoxyguanosine Kinase (DGUOK) Antibodies
    Deoxyguanosine Kinase (DGUOK)
    Binding Specificity
    • 10
    • 9
    • 7
    • 7
    • 5
    • 1
    • 1
    C-Term
    Reactivity
    • 41
    • 11
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse
    Host
    • 39
    • 2
    Rabbit
    Clonality
    • 39
    • 2
    Polyclonal
    Conjugate
    • 17
    • 6
    • 5
    • 5
    • 4
    • 4
    This Deoxyguanosine Kinase antibody is un-conjugated
    Application
    • 34
    • 34
    • 4
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Specificity
    This antibody reacts to Deoxyguanosine Kinase (DGUOK).
    Purification
    Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
    Immunogen
    This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human DGUOK.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product DGUOK Primary Antibody
  • Application Notes
    ELISA: 1/1,000. Western blotting: 1/100 - 1/500.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.25 mg/mL
    Buffer
    PBS with 0.09 % (W/V) sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • Target
    Deoxyguanosine Kinase (DGUOK)
    Alternative Name
    Deoxyguanosine Kinase (DGUOK Products)
    Synonyms
    DGUOK antibody, zgc:86625 antibody, dgk antibody, DDBDRAFT_0218264 antibody, DDBDRAFT_0233982 antibody, DDB_0218264 antibody, DDB_0233982 antibody, MTDPS3 antibody, dGK antibody, dGK1 antibody, dGK2 antibody, dGK3 antibody, deoxyguanosine kinase antibody, deoxyguanosine kinase L homeolog antibody, DGUOK antibody, dguok antibody, dguok.L antibody, dgk antibody, Ccan_04750 antibody, Dguok antibody
    Background
    Mitochondrial deoxyguanosine kinase (DGUOK) is required for the phosphorylation of several deoxyribonucleosides and certain purine deoxykribonucleoside analogs widely employed as antiviral and chemotherapeutic agents. Purine deoxyribonucleoside analogs are extensively used in treatment of lymphoproliferative disorders. These compounds are administered as pro-drugs, and their efficiency is dependent on intracellular phosphorylation to the corresponding triphosphates. In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by 2 deoxyribonucleoside kinases: cytosolic deoxycytidine kinase (DCK) and mitochondrial deoxyguanosine kinase (DGUOK also known as DGK). DGUOK expression is ubiquitous, with highest levels in muscle, brain, liver and lymphoid tissues. Defects in DGUOK are a cause of mitochondrial DNA depletion syndrome (MDS). MDS is a clinically heterogeneous group of disorders characterized by a reduction in mitochondrial DNA (mtDNA) copy number. Primary mtDNA depletion is inherited as an autosomal recessive trait and may affect single organs, typically muscle or liver, or multiple tissues. Mitochondrial DNA depletion syndromes are phenotypically heterogeneous, autosomal recessive disorders characterized by tissue-specific reduction in mtDNA copy number. Affected individuals with the hepatocerebral form of mtDNA depletion syndrome have early progressive liver failure and neurologic abnormalities, hypoglycemia, and increased lactate in body fluids.Synonyms: DGK, DGUOK
    Gene ID
    1716, 9606
    UniProt
    Q16854
    Pathways
    Ribonucleoside Biosynthetic Process
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