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RIPK3 antibody (Receptor-Interacting serine-threonine Kinase 3) (Middle Region)

Details for Product anti-RIPK3 Antibody No. ABIN359363, Supplier: Log in to see
Antigen
  • 2610528K09Rik
  • AW107945
  • Hcyp2
  • Rip3
  • RIP3
  • RIPK3
Epitope
Middle Region
32
20
16
15
10
7
5
5
4
3
3
2
2
2
2
2
2
2
1
1
1
1
Reactivity
Human, Mouse (Murine)
113
38
15
7
6
4
2
1
Host
Rabbit
120
23
Clonality
Polyclonal
Conjugate
This RIPK3 antibody is un-conjugated
9
7
5
5
5
5
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
128
60
59
25
7
3
2
2
2
1
Supplier
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human RIPK3.
Isotype Ig
Specificity This antibody detects RIPK3 / RIP3.
Purification Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Alternative Name RIPK3 / RIP3 (RIPK3 Antibody Abstract)
Background The product of the RIPK3 gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor.Synonyms: RIP-3, RIP-like protein kinase 3, Receptor-interacting protein 3, Receptor-interacting serine/threonine-protein kinase 3
Molecular Weight 56901 Da.
Gene ID 11035, 9606
UniProt Q9Y572
Application Notes ELISA1: 1,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-RIPK3 antibody (Receptor-Interacting serine-threonine Kinase 3) (Middle Region) (ABIN359363) Immunohistochemistry analysis in human lung carcinoma tissue (Formalin-fixed, Paraffi...
Western Blotting (WB) image for anti-RIPK3 antibody (Receptor-Interacting serine-threonine Kinase 3) (Middle Region) (ABIN359363) Western blot analysis of RIPK3 (arrow) in Hela cell line lysates (35ug/lane) using RI...
Western Blotting (WB) image for anti-RIPK3 antibody (Receptor-Interacting serine-threonine Kinase 3) (Middle Region) (ABIN359363) Western blot analysis of RIPK3 (arrow) in mouse cerebellum tissue lysates (35ug/lane)...
Background publications Yu, Huang, Shen, Quast, Chan, Xu, Nolan, Payan, Luo: "Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB." in: Current biology : CB, Vol. 9, Issue 10, pp. 539-42, 1999

Sun, Lee, Navas, Baldwin, Stewart, Dixit: "RIP3, a novel apoptosis-inducing kinase." in: The Journal of biological chemistry, Vol. 274, Issue 24, pp. 16871-5, 1999