Receptor-Interacting serine-threonine Kinase 3 (RIPK3) (Middle Region) antibody

Details for Product No. ABIN359363
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Antigen
Synonyms RIP3, Hcyp2, 2610528K09Rik, AW107945, Rip3, RIPK3
Epitope
Middle Region
(7), (5), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(55), (31), (20), (15), (14), (12), (12), (3)
Host
Rabbit
(67), (7)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA
(58), (23), (22), (10), (10), (6), (6), (3), (2), (1), (1)
Pubmed 2 references available
Catalog no. ABIN359363
Quantity 0.4 mL
Price
357.50 $   Plus shipping costs $45.00
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human RIPK3.
Specificity This antibody detects RIPK3 / RIP3.
Purification Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Alternative Name RIPK3 / RIP3
Background The product of the RIPK3 gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor.
Alternate names: RIP-3, RIP-like protein kinase 3, Receptor-interacting protein 3, Receptor-interacting serine/threonine-protein kinase 3
Molecular Weight 56901 Da.
Gene ID 11035
NCBI Accession 9606
UniProt Q9Y572
Application Notes ELISA1: 1,000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) sodium azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Yu, Huang, Shen et al.: "Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB." in: Current biology : CB, Vol. 9, Issue 10, pp. 539-42, 1999 (PubMed).

Sun, Lee, Navas et al.: "RIP3, a novel apoptosis-inducing kinase." in: The Journal of biological chemistry, Vol. 274, Issue 24, pp. 16871-5, 1999 (PubMed).

Hosts (67), (7)
Reactivities (55), (31), (20), (15), (14), (12), (12), (3)
Applications (58), (23), (22), (10), (10), (6), (6), (3), (2), (1), (1)
Conjugates (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (7), (5), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
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