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Details for Product No. ABIN359544

Cyclin A2 (CCNA2) (N-Term) antibody

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Antigen
Synonyms CCN1, CCNA, AA408589, Ccn-1, Ccn1, Ccna, CycA2, Cyca, cb671, chunp6924, wu:fi36f03, CYCA, Cyclin-A2, ccna2, ccn1, ccna, ccna1
Epitope
»Alternatives N-Term
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN359544
Quantity 0.4 mL
Price
346.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide at the N-term of human CCNA2.
Specificity This antibody reacts to Cyclin A (CCNA2).
Purification Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
Alternative Name Cyclin A2
Background CCNA2 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions.
Alternate names: CCN1, CCNA, CCNA2, Cyclin A, Cyclin-A2
Gene ID 890
NCBI Accession 9606
UniProt P20248
Research Area Cell Cycle
Application Notes ELISA: 1/1,000. Western blotting: 1/50 - 1/100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) sodium azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
Expiry Date 12 months
Background publications Wang, Chenivesse, Henglein et al.: "Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma." in: Nature, Vol. 343, Issue 6258, pp. 555-7, 1990 (PubMed).

Henglein, Chenivesse, Wang et al.: "Structure and cell cycle-regulated transcription of the human cyclin A gene." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 12, pp. 5490-4, 1994 (PubMed).

Tsang, Wang, Chen et al.: "SCAPER, a novel cyclin A-interacting protein that regulates cell cycle progression." in: The Journal of cell biology, Vol. 178, Issue 4, pp. 621-33, 2007 (PubMed).

Alternatives for antigen "Cyclin A2 (CCNA2)", type "Antibodies"
Hosts (81), (65)
Reactivities (122), (53), (38), (30), (5), (3), (2), (2), (2), (1), (1), (1)
Applications (117), (56), (39), (29), (27), (21), (14), (11), (10), (3), (3), (2), (1), (1), (1)
Conjugates (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (20), (10), (2), (2), (2), (1), (1), (1)
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