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Cyclin A antibody (Cyclin A2) (C-Term)

Details for Product anti-CCNA2 Antibody No. ABIN359545, Supplier: Log in to see
Antigen
  • ccn1
  • ccna
  • ccna1
  • CCN1
  • CCNA
  • AA408589
  • Ccn-1
  • Ccn1
  • Ccna
  • CycA2
  • Cyca
  • cb671
  • chunp6924
  • wu:fi36f03
  • CYCA
  • Cyclin-A2
  • ccna2
  • Cyclin-A
  • cyclinA
  • cyclin A2
  • cyclin A
  • ccna2
  • CCNA2
  • LOC100352785
  • Ccna2
  • LOC397933
Alternatives
anti-Human Cyclin A antibody for ELISA
Epitope
C-Term
25
21
12
5
5
4
4
3
3
2
2
2
1
1
1
1
1
1
Reactivity
Human
249
134
84
55
21
21
21
19
4
3
3
3
3
3
2
2
1
1
Host
Rabbit
189
101
1
Clonality
Polyclonal
Conjugate
This Cyclin A antibody is un-conjugated
9
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
6
6
2
2
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
238
89
79
78
57
54
53
43
41
4
4
4
3
3
2
2
1
1
Options
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human CCNA2.
Isotype Ig
Specificity This antibody reacts to CCNA2.
Purification Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
Alternative Name Cyclin A2 (CCNA2 Antibody Abstract)
Background CCNA2 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions.Synonyms: CCN1, CCNA, CCNA2, Cyclin A, Cyclin-A2
Gene ID 890, 9606
UniProt P20248
Research Area Cell Cycle
Pathways PI3K-Akt Signaling, Cell Division Cycle, AMPK Signaling, Mitotic G1-G1/S Phases, DNA Replication, M Phase
Application Notes ELISA: 1/1,000. Western Blot. Immunohistochemistry: 1/10 - 1/50.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Cyclin A antibody (Cyclin A2) (C-Term) (ABIN359545) Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with CCNA2...
Western Blotting (WB) image for anti-Cyclin A antibody (Cyclin A2) (C-Term) (ABIN359545) Western blot analysis of CCNA2 (arrow) using rabbit polyclonal CCNA2 Antibody
Background publications Henglein, Chenivesse, Wang, Eick, Bréchot: "Structure and cell cycle-regulated transcription of the human cyclin A gene." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 12, pp. 5490-4, 1994 (PubMed).

Wang, Chenivesse, Henglein, Bréchot: "Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma." in: Nature, Vol. 343, Issue 6258, pp. 555-7, 1990 (PubMed).