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ABCC4 antibody (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4) (C-Term)

Details for Product anti-ABCC4 Antibody No. ABIN359599, Supplier: Log in to see
Antigen
  • EST170205
  • MOAT-B
  • MOATB
  • MRP4
  • D630049P08Rik
  • Mrp4
Epitope
C-Term
22
18
9
8
7
5
4
3
2
2
2
1
1
Reactivity
Human
100
40
32
1
1
1
1
Host
Rabbit
46
40
17
8
Clonality
Polyclonal
Conjugate
This ABCC4 antibody is un-conjugated
4
4
4
3
3
3
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
87
54
37
22
14
11
7
7
4
3
2
1
Supplier
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human ABCC4.
Isotype Ig
Specificity This antibody reacts to ABCC4.
Purification Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
Alternative Name ABCC4 / MRP4 (ABCC4 Antibody Abstract)
Background ABCC4 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC proteins are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined, however, this protein may play a role in cellular detoxification as a pump for its substrate, organic anions.Synonyms: ATP-binding cassette sub-family C member 4, MOAT-B, MRP/cMOAT-related ABC transporter, Multi-specific organic anion transporter B, Multidrug resistance-associated protein 4
Gene ID 10257, 9606
UniProt O15439
Application Notes ELISA: 1/1,000. Western blotting: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-ABCC4 antibody (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4) (C-Term) (ABIN359599) Western blot analysis of anti-ABCC4 Antibody (C-term) in CEM cell line lysates (35ug/...
Background publications Janke, Mehralivand, Strand et al.: "6-mercaptopurine and 9-(2-phosphonyl-methoxyethyl) adenine (PMEA) transport altered by two missense mutations in the drug transporter gene ABCC4." in: Human mutation, Vol. 29, Issue 5, pp. 659-69, 2008 (PubMed).

Adachi, Sampath, Lan et al.: "Expression of MRP4 confers resistance to ganciclovir and compromises bystander cell killing." in: The Journal of biological chemistry, Vol. 277, Issue 41, pp. 38998-9004, 2002 (PubMed).

Lee, Belinsky, Bell et al.: "Isolation of MOAT-B, a widely expressed multidrug resistance-associated protein/canalicular multispecific organic anion transporter-related transporter." in: Cancer research, Vol. 58, Issue 13, pp. 2741-7, 1998 (PubMed).

Kool, de Haas, Scheffer et al.: "Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines." in: Cancer research, Vol. 57, Issue 16, pp. 3537-47, 1997 (PubMed).