ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4) (C-Term) antibody

Antigen: ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4)

Synonyms: ADMP-1, ADAMTS-2, ADAMTS-4, KIAA0688, KIAA0366, ADAM-TS4, mKIAA0688, 3830423K05, ADAMTS4, DKFZp469J0817, AAC2, PNAT, NPI, PCINP, PCPNI, hPCPNI, ADAM-TS2, ADAMTS-3, TTP, VWFCP, C9orf8, vWF-CP, FLJ42993, MGC118899, MGC118900, DKFZp434C2322, ADMP-2, ADAMTS11, FLJ36738, ASMP-2, ADAMTS1, ADAM-TS5, AI481094, 9530092O11Rik, PWTSR, THSD2, CRISTIN1, FLJ14440, AW743315, 1810011L16Rik, 8430403M15Rik, E030027K14Rik, FLJ16042, AU015154, 4831407I23Rik, D230034E10Rik, Gm710, ADAMTS5, ADAMTS13, ADAMTS-11

Epitope: C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Enzyme Immunoassay (EIA), Western Blotting (WB)

Catalog no.: ABIN359602

Additional Information

Characteristics: Synonyms: ADAMTS-4, ADAM-TS4, Aggrecanase-1, ADMP1, ADMP-1, KIAA0688, A disintegrin andmetalloproteinase with thrombospondin motifs 4

Alternative name: ADAMTS4

Gene ID: 9507

Swiss-Prot: O75173

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated syntheticpeptide selected from the C-terminal region of human ADAMTS4.

Cross-Reactivity: Human, Mouse (Murine)

Isotype: Ig  (Matching secondary antibodies)

Description: ADAMTS4 is a member of the ADAMTS (a disintegrin and metalloproteinase withthrombospondin motifs) protein family. Members of the family share several distinctprotein modules, including a propeptide region, a metalloproteinase domain, adisintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members ofthis family differ in the number of C-terminal TS motifs, and some have unique C-terminaldomains. The enzyme lacks a C-terminal TS motif. It is responsible for the degradation ofaggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellularmatrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme inarthritic disease and in the central nervous system, potentially, in the progression ofglioma.

Specificity: This antibody reacts to ADAMTS4. Species: Human, Mouse. Others not tested.

Synonyms: ADMP-1, ADAMTS-2, ADAMTS-4, KIAA0688, KIAA0366, ADAM-TS4, mKIAA0688, 3830423K05, ADAMTS4, DKFZp469J0817, AAC2, PNAT, NPI, PCINP, PCPNI, hPCPNI, ADAM-TS2, ADAMTS-3, TTP, VWFCP, C9orf8, vWF-CP, FLJ42993, MGC118899, MGC118900, DKFZp434C2322, ADMP-2, ADAMTS11, FLJ36738, ASMP-2, ADAMTS1, ADAM-TS5, AI481094, 9530092O11Rik, PWTSR, THSD2, CRISTIN1, FLJ14440, AW743315, 1810011L16Rik, 8430403M15Rik, E030027K14Rik, FLJ16042, AU015154, 4831407I23Rik, D230034E10Rik, Gm710, ADAMTS5, ADAMTS13, ADAMTS-11

Application Details

Application Notes: ELISA: 1/1,000. Western blotting: 1/50 - 1/100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Concentration: 0.25 mg/ml

Purification: Aff - Purified

Buffer: PBS with 0.09% (W/V) sodium azide

Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. Caution: This product is for research use only. Not for use in diagnostic or therapeutic procedures.

Restrictions: For Research Use only