Sprouty Homolog 4 (C-Term) antibody

Details for Product No. ABIN359610
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Antigen
Epitope
C-Term
(2), (1), (1)
Reactivity
Human
(6), (3), (3), (3), (3), (1)
Host
Rabbit
(7)
Clonality
Polyclonal
Application
ELISA, Western Blotting (WB)
(6), (6), (4), (1), (1)
Pubmed 3 references available
Catalog no. ABIN359610
Quantity 0.4 mL
Price
357.50 $   Plus shipping costs $45.00
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human SPRY4.
Specificity This antibody reacts to SPRY4.
Purification Protein A column, followed by peptide affinity purification
Alternative Name Sprouty homolog 4 / SPRY4
Background SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. The protein is positioned upstream of RAS activation and impairs the formation of active GTP-RAS.
Alternate names: Sprouty 4, Spry-4
Gene ID 81848
NCBI Accession 9606
UniProt Q9C004
Application Notes ELISA: 1/1,000. Western blotting: 1/50 - 1/100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) sodium azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
Expiry Date 12 months
Background publications Tsumura, Toshima, Leeksma et al.: "Sprouty-4 negatively regulates cell spreading by inhibiting the kinase activity of testicular protein kinase." in: The Biochemical journal, Vol. 387, Issue Pt 3, pp. 627-37, 2005 (PubMed).

Wolf-Yadlin, Hautaniemi, Lauffenburger et al.: "Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 14, pp. 5860-5, 2007 (PubMed).

Rikova, Guo, Zeng et al.: "Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." in: Cell, Vol. 131, Issue 6, pp. 1190-203, 2007 (PubMed).

Hosts (7)
Reactivities (6), (3), (3), (3), (3), (1)
Applications (6), (6), (4), (1), (1)
Epitopes (2), (1), (1)
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