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DYRK1A antibody (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A) (N-Term)

Details for Product anti-DYRK1A Antibody No. ABIN359711, Supplier: Log in to see
Antigen
  • DYRK1A
  • dyrk
  • dyrk1
  • hp86
  • mnb
  • mnbh
  • DYRK
  • DYRK1
  • HP86
  • MNB
  • MNBH
  • MRD7
  • 2310043O08Rik
  • D16Ertd272e
  • D16Ertd493e
  • Dyrk
  • ENSMUSG00000074897
  • Gm10783
  • Mnbh
  • Mp86
  • mmb
  • PSK47
Epitope
N-Term
35
25
15
15
11
3
3
3
2
2
1
1
1
1
1
1
1
Reactivity
Human
114
38
31
2
1
1
1
Host
Rabbit
105
9
5
2
Clonality
Polyclonal
Conjugate
This DYRK1A antibody is un-conjugated
8
8
8
7
7
7
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
102
70
11
9
8
7
4
3
3
2
2
Supplier
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human DYRK1A.
Isotype Ig
Specificity This antibody reacts to DYRK1A.
Purification Protein A column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Alternative Name DYRK1A (DYRK1A Antibody Abstract)
Background DYRK1A is a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. The DYRK1A gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome.Synonyms: DYRK, Dual specificity YAK1-related kinase, Dual specificity tyrosine-phosphorylation-regulated kinase 1A, HP86, MNB, MNBH, Protein kinase minibrain homolog
Gene ID 1859, 9606
UniProt Q13627
Research Area Neurology, Neurogenesis
Application Notes ELISA: 1/1,000. Western blotting: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-DYRK1A antibody (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A) (N-Term) (ABIN359711) Western blot analysis of DYRK1A Antibody (N-term) in 293 cell line lysates (35ug/lane...
Background publications Adayev, Chen-Hwang, Murakami et al.: "Dual-specificity tyrosine phosphorylation-regulated kinase 1A does not require tyrosine phosphorylation for activity in vitro." in: Biochemistry, Vol. 46, Issue 25, pp. 7614-24, 2007 (PubMed).

Chang, Lin, Yang et al.: "Increased expression of Dyrk1a in HPV16 immortalized keratinocytes enable evasion of apoptosis." in: International journal of cancer. Journal international du cancer, Vol. 120, Issue 11, pp. 2377-85, 2007 (PubMed).

Alvarez, Altafaj, Aranda et al.: "DYRK1A autophosphorylation on serine residue 520 modulates its kinase activity via 14-3-3 binding." in: Molecular biology of the cell, Vol. 18, Issue 4, pp. 1167-78, 2007 (PubMed).

Wissing, Jänsch, Nimtz et al.: "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry." in: Molecular & cellular proteomics : MCP, Vol. 6, Issue 3, pp. 537-47, 2007 (PubMed).