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DDR1 antibody

DDR1 Reactivity: Human WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN359899
  • Target See all DDR1 Antibodies
    DDR1 (Discoidin Domain Receptor tyrosine Kinase 1 (DDR1))
    Reactivity
    • 88
    • 43
    • 43
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    Human
    Host
    • 94
    • 9
    Rabbit
    Clonality
    • 93
    • 9
    • 1
    Polyclonal
    Conjugate
    • 50
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This DDR1 antibody is un-conjugated
    Application
    • 82
    • 43
    • 26
    • 26
    • 24
    • 14
    • 10
    • 6
    • 5
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificity
    This antibody reacts to MCK10.
    Purification
    Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
    Immunogen
    This antibody is generated from rabbits immunized with recombinant human MCK10 protein.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product DDR1 Primary Antibody
  • Application Notes
    ELISA: 1/1,000. Western blotting: 1/50 - 1/100. Immunohistochemistry: 1/10 - 1/50.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.25 mg/mL
    Buffer
    PBS with 0.09 % (W/V) sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • Target
    DDR1 (Discoidin Domain Receptor tyrosine Kinase 1 (DDR1))
    Alternative Name
    CD167a / DDR1 (DDR1 Products)
    Synonyms
    CG11573 antibody, CG13984 antibody, CG13985 antibody, CG33531 antibody, CG9488 antibody, CG9490 antibody, CT33540 antibody, DDR antibody, Dmel\\CG33531 antibody, Dmel_CG13984 antibody, 6030432F18 antibody, AI323681 antibody, CD167a antibody, Cak antibody, Nep antibody, PTK3A antibody, CAK antibody, CD167 antibody, EDDR1 antibody, HGK2 antibody, MCK10 antibody, NEP antibody, NTRK4 antibody, PTK3 antibody, RTK6 antibody, TRKE antibody, Drd1 antibody, PTK3D antibody, Discoidin domain receptor antibody, discoidin domain receptor family, member 1 antibody, discoidin domain receptor tyrosine kinase 1 antibody, Ddr antibody, Ddr1 antibody, DDR1 antibody
    Background
    Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. MCK10 is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain.Synonyms: CAK, CD167 antigen-like family member A, EDDR1, Epithelial discoidin domain receptor 1, Epithelial discoidin domain-containing receptor 1, MCK10, NEP, NTRK4, PTK3A, RTK6, TRKE, Tyrosine kinase DDR-1
    Gene ID
    780, 9606
    UniProt
    Q08345
    Pathways
    RTK Signaling, Smooth Muscle Cell Migration
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