beta-Site APP-Cleaving Enzyme 1 (BACE) (N-Term) antibody

Details for Product No. ABIN360082, Supplier: Log in to see
Antigen
  • BACE1
  • MGC145931
  • bace2
  • MGC68881
  • MGC68482
  • BACE2
  • C76936
  • Bace
  • ASP2
  • BACE
  • HSPC104
  • zgc:77409
  • beta-site APP-cleaving enzyme 1
  • beta-site APP-cleaving enzyme 2
  • beta-site APP cleaving enzyme 1
  • BACE1
  • MGC145931
  • LOC100232107
  • bace2
  • BACE2
  • LOC100224177
  • Bace1
  • bace1
Epitope
N-Term
42
38
20
19
15
12
9
9
6
5
5
5
5
4
4
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
251
161
116
21
12
12
8
7
7
7
6
6
5
3
3
2
1
1
Host
Rabbit
191
70
5
Clonality
Polyclonal
Conjugate
Un-conjugated
9
8
6
6
5
5
4
4
4
4
4
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
169
98
73
46
42
31
29
26
16
4
3
3
2
2
1
Options
Supplier
Log in to see
Supplier Product No.
Log in to see
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human BACE1.
Isotype Ig
Specificity This antibody reacts to BACE1.
Purification Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
Alternative Name BACE1 (BACE Antibody Abstract)
Background Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is BACE. This protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi.Synonyms: ASP2, Aspartyl protease 2, BACE, BACE-1, Beta-secretase 1, Beta-site APP cleaving enzyme 1, Beta-site amyloid precursor protein cleaving enzyme 1, KIAA1149, Memapsin-2, Membrane-associated aspartic protease 2
Gene ID 23621, 9606
UniProt P56817
Research Area Proteolysis / Ubiquitin, Alzheimer's Disease, Enzymes
Application Notes ELISA: 1/1,000. Western blot: 1/50 - 1/100. Immunohistochemistry on paraffin sections: 1/10 - 1/50.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Supplier Images
 image for anti-beta-Site APP-Cleaving Enzyme 1 (BACE) (N-Term) antibody (ABIN360082) anti-beta-Site APP-Cleaving Enzyme 1 (BACE) (N-Term) antibody
 image for anti-beta-Site APP-Cleaving Enzyme 1 (BACE) (N-Term) antibody (ABIN360082) anti-beta-Site APP-Cleaving Enzyme 1 (BACE) (N-Term) antibody (Image 2)
Background publications Xie, Guo: "PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein." in: The Journal of biological chemistry, Vol. 280, Issue 14, pp. 13824-32, 2005 (PubMed).

He, Li, Chang, Tang: "GGA proteins mediate the recycling pathway of memapsin 2 (BACE)." in: The Journal of biological chemistry, Vol. 280, Issue 12, pp. 11696-703, 2005 (PubMed).

Did you look for something else?