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Receptor-Interacting serine-threonine Kinase 3 (RIPK3) (C-Term) antibody

Details for Product No. ABIN360159, Supplier: Log in to see
Antigen
  • RIPK3
  • RIP3
  • 2610528K09Rik
  • AW107945
  • Rip3
  • Hcyp2
Epitope
C-Term
31
20
16
15
10
7
5
5
4
3
3
2
2
2
2
2
2
2
2
1
1
1
Reactivity
Human, Mouse (Murine)
114
39
16
7
6
4
2
1
Host
Rabbit
121
23
Clonality
Polyclonal
Conjugate
Un-conjugated
9
7
5
5
5
5
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
128
61
60
22
7
3
2
2
2
1
1
1
Supplier
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human RIPK3.
Isotype Ig
Specificity This antibody reacts to RIP3 (RIPK3).
Purification Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Alternative Name RIPK3 / RIP3 (RIPK3 Antibody Abstract)
Background RIPK3 is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor.Synonyms: RIP-3, RIP-like protein kinase 3, Receptor-interacting protein 3, Receptor-interacting serine/threonine-protein kinase 3
Gene ID 11035
NCBI Accession NP_006862
UniProt Q9Y572
Pathways
Application Notes ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Supplier Images
 image for anti-Receptor-Interacting serine-threonine Kinase 3 (RIPK3) (C-Term) antibody (ABIN360159) anti-Receptor-Interacting serine-threonine Kinase 3 (RIPK3) (C-Term) antibody
 image for anti-Receptor-Interacting serine-threonine Kinase 3 (RIPK3) (C-Term) antibody (ABIN360159) anti-Receptor-Interacting serine-threonine Kinase 3 (RIPK3) (C-Term) antibody (Image 2)
Background publications Sun, Lee, Navas et al.: "RIP3, a novel apoptosis-inducing kinase." in: The Journal of biological chemistry, Vol. 274, Issue 24, pp. 16871-5, 1999 (PubMed).

Yu, Huang, Shen et al.: "Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB." in: Current biology : CB, Vol. 9, Issue 10, pp. 539-42, 1999 (PubMed).