Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, gamma (PIP5K1C) (N-Term) antibody

Details for Product No. ABIN360480
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Antigen
Synonyms MGC130766, PIP5K1C, pip5k1a, zgc:110576, si:dkey-29i9.1, AI115456, AI835305, Pip5kIgamma, LCCS3, PIP5K-GAMMA, PIP5Kgamma, PIPKIg_v4
Epitope
N-Term
(9), (7), (3), (2), (2), (1), (1), (1)
Reactivity
Human
(35)
Host
Rabbit
(32), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2)
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(34), (28), (12), (5), (2), (2), (1)
Pubmed 3 references available
Quantity 0.4 mL
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Catalog No. ABIN360480
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human PIP5K1G.
Specificity This antibody reacts to PIP5Ki gamma.
Purification Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Alternative Name PIP5K1C
Background Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.
Alternate names: KIAA0589, PIP5K1-gamma, PIP5KIgamma, Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma, PtdIns(4)P-5-kinase 1 gamma
Gene ID 23396, 9606
UniProt O60331
Application Notes ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/50 - 1/100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
Expiry Date 12 months
Supplier Images
anti-Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, gamma (PIP5K1C) (N-Term) antibody anti-Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, gamma (PIP5K1C) (N-Term) antibody
anti-Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, gamma (PIP5K1C) (N-Term) antibody (2) anti-Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, gamma (PIP5K1C) (N-Term) antibody (Image 2)
Background publications Ishihara, Shibasaki, Kizuki et al.: "Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/substitution analysis of members of this novel lipid kinase family." in: The Journal of biological chemistry, Vol. 273, Issue 15, pp. 8741-8, 1998 (PubMed).

Di Paolo, Pellegrini, Letinic et al.: "Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin." in: Nature, Vol. 420, Issue 6911, pp. 85-9, 2002 (PubMed).

Ling, Doughman, Firestone et al.: "Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions." in: Nature, Vol. 420, Issue 6911, pp. 89-93, 2002 (PubMed).

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