WNK Lysine Deficient Protein Kinase 1 (WNK1) (Middle Region) antibody

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Middle Region
(24), (18), (16), (7), (7), (7), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Human, Mouse (Murine)
(123), (48), (48), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
(123), (1)
(6), (4), (4), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
ELISA, Western Blotting (WB)
(63), (45), (44), (24), (22), (9), (5), (4), (1), (1), (1)
Pubmed 4 references available
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Quantity 0.1 mg
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human WNK1.
Specificity This antibody reacts to WNK1.
Purification Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Alternative Name WNK1 (WNK1 Antibody Abstract)
Background The WNK1 gene encodes a cytoplasmic serine-threonine kinase expressed in distal nephron.[supplied by OMIM]
Alternate names: Erythrocyte 65 kDa protein, KDP, KIAA0344, Kinase deficient protein, PRKWNK1, Protein kinase lysine-deficient 1, Protein kinase with no lysine 1, Serine/threonine-protein kinase WNK1, p65
Gene ID 65125
NCBI Accession NP_001171914
UniProt Q9H4A3
Research Area Signaling, Kinases/Phosphatases
Application Notes ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
Expiry Date 12 months
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Image no. 1 for anti-WNK Lysine Deficient Protein Kinase 1 (WNK1) (Middle Region) antibody (ABIN360582) anti-WNK Lysine Deficient Protein Kinase 1 (WNK1) (Middle Region) antibody
Background publications Xu, Min, Stippec et al.: "Regulation of WNK1 by an autoinhibitory domain and autophosphorylation." in: The Journal of biological chemistry, Vol. 277, Issue 50, pp. 48456-62, 2002 (PubMed).

Veríssimo, Jordan: "WNK kinases, a novel protein kinase subfamily in multi-cellular organisms." in: Oncogene, Vol. 20, Issue 39, pp. 5562-9, 2001 (PubMed).

Wilson, Disse-Nicodème, Choate et al.: "Human hypertension caused by mutations in WNK kinases." in: Science (New York, N.Y.), Vol. 293, Issue 5532, pp. 1107-12, 2001 (PubMed).

Moore, Garg, Johnson et al.: "PSK, a novel STE20-like kinase derived from prostatic carcinoma that activates the c-Jun N-terminal kinase mitogen-activated protein kinase pathway and regulates actin cytoskeletal organization." in: The Journal of biological chemistry, Vol. 275, Issue 6, pp. 4311-22, 2000 (PubMed).