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TRPM8 antibody (Transient Receptor Potential Cation Channel, Subfamily M, Member 8) (Middle Region)

Details for Product anti-TRPM8 Antibody No. ABIN360716, Supplier: Log in to see
Antigen
  • CMR1
  • LTrpC-6
  • LTRPC6
  • ltrpc6
  • Trp-p8
  • TRPM8
  • trpm8b
  • TRPP8
  • trpp8
Epitope
Middle Region
28
14
13
13
13
9
5
4
3
3
3
3
3
3
2
2
2
2
2
2
1
1
1
Reactivity
Human
117
58
47
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Host
Rabbit
128
14
2
Clonality
Polyclonal
Conjugate
This TRPM8 antibody is un-conjugated
6
4
3
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
92
56
42
41
20
14
11
6
3
Supplier
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide at the Center(R536) of human TRPM8.
Isotype Ig
Specificity This antibody reacts to TRPM8.
Purification Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
Alternative Name TRPM8 (TRPM8 Antibody Abstract)
Background TRPM8 is a receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. It is activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH and involved in menthol sensation. It is permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium.Synonyms: LTRPC6, Long transient receptor potential channel 6, TRPP8, Transient receptor potential cation channel subfamily M member 8, Transient receptor potential-p8, Trp-p8
Gene ID 79054, 9606
UniProt Q7Z2W7
Research Area Neurology, Metabolism
Application Notes ELISA: 1/1,000. Western blotting: 1/50 - 1/100. Immunohistochemistry: 1/10 - 1/50.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Supplier Images
 image for anti-TRPM8 antibody (Transient Receptor Potential Cation Channel, Subfamily M, Member 8) (Middle Region) (ABIN360716) anti-Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8) (Middle Region) antibody
 image for anti-TRPM8 antibody (Transient Receptor Potential Cation Channel, Subfamily M, Member 8) (Middle Region) (ABIN360716) anti-Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8) (Middle Region) antibody (Image 2)
Background publications Bödding, Wissenbach, Flockerzi: "Characterisation of TRPM8 as a pharmacophore receptor." in: Cell calcium, Vol. 42, Issue 6, pp. 618-28, 2007

Kiessling, Füssel, Schmitz, Stevanovic, Meye, Weigle, Klenk, Wirth, Rieber: "Identification of an HLA-A*0201-restricted T-cell epitope derived from the prostate cancer-associated protein trp-p8." in: The Prostate, Vol. 56, Issue 4, pp. 270-9, 2003

Tsavaler, Shapero, Morkowski, Laus: "Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins." in: Cancer research, Vol. 61, Issue 9, pp. 3760-9, 2001

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