Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

IL-6 Receptor antibody (Extracellular Domain)

IL6R Reactivity: Mouse WB, IHC (fro) Host: Rat Monoclonal 14F33 unconjugated
Catalog No. ABIN360909
  • Target See all IL-6 Receptor (IL6R) Antibodies
    IL-6 Receptor (IL6R) (Interleukin 6 Receptor (IL6R))
    Binding Specificity
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Extracellular Domain
    Reactivity
    • 49
    • 19
    • 15
    Mouse
    Host
    • 47
    • 22
    • 4
    • 1
    • 1
    Rat
    Clonality
    • 50
    • 24
    • 1
    Monoclonal
    Conjugate
    • 48
    • 13
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This IL-6 Receptor antibody is un-conjugated
    Application
    • 50
    • 23
    • 22
    • 21
    • 12
    • 9
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Specificity
    This antibody detects Mouse IL-6R. Other species not tested.
    Purification
    Protein A/G affinity chromatography
    Immunogen
    Recombinant protein of IL-6R extracellular domain.
    Clone
    14F33
    Isotype
    IgG2
    Top Product
    Discover our top product IL6R Primary Antibody
  • Application Notes
    Western Blot: 1/500 - 1/1000.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Reconstitution
    Restore with 0.2 mL sterile PBS and the final concentration is 0.5 mg/mL.
    Buffer
    PBS, None
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    IL-6 Receptor (IL6R) (Interleukin 6 Receptor (IL6R))
    Alternative Name
    CD126 / IL6R (IL6R Products)
    Synonyms
    IL6R antibody, il-6ra antibody, CD126 antibody, IL-6R-1 antibody, IL-6RA antibody, IL6Q antibody, IL6RA antibody, IL6RQ antibody, gp80 antibody, IL6R1 antibody, Il6ra antibody, IL-6Ralpha antibody, IL-6R antibody, Il6r antibody, interleukin 6 receptor antibody, interleukin 6 receptor, alpha antibody, IL6R antibody, il6r antibody, Il6r antibody, Il6ra antibody
    Background
    IL6 exerts its activity through binding to a high affinity receptor complex consisting of two membrane glycoproteins: an 80 kDa IL6 binding receptor protein (IL6R) and a 130 kDa signal transducing protein consisting of a 19 amino acid residue signal peptide (gp130). Human IL6R is a 468 amino acid residue type I membrane protein consisting of a 19 amino acid residue signal peptide, a 339 residue extracellular region, a 28 residue transmembrane region and an 82 residue cytoplasmic region. The ectodomain of IL6R is made up of an immunoglobulin like domain and a cytokine receptor superfamily domain. A naturally occurring soluble form of the IL6R, which binds IL6 and which mediates IL6 signaling through interaction with gp130, is identified in the urine of healthy adult humans. It has also been detected in human and mouse serum as well as in the conditioned medium of various cells including human peripheral blood mononuclear cells, and several T cell or granulocyte/macrophage cell lines. Increased expression of the c-fos and c-myc protooncogenes have been linked to IL6 receptor activation.Synonyms: IL-6R 1, IL-6R-alpha, IL6 Receptor alpha, Interleukin-6 receptor subunit alpha, Membrane glycoprotein 80
    Gene ID
    16194
    NCBI Accession
    NP_034689
    UniProt
    P22272
    Pathways
    JAK-STAT Signaling, Autophagy, Growth Factor Binding, Cancer Immune Checkpoints
You are here:
Support