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Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) antibody

Antigen

Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8)
Synonyms CAP4, MACH, MCH5, FLICE, ALPS2B, Casp-8, FLJ17672, MGC78473, Mch5, Caspase-8, MGC92075, caspase-8, zgc:92075, casp8-A, xCaspase-8, CASP8, casp8, DKFZp469A1428
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human, Rat (Rattus), Mouse (Murine)
Application
Alternatives Western Blotting (WB)
Catalog no. ABIN361204
Quantity 100ug  (Variants)
Price 283.33 $   Plus shipping costs $35.00
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anti-Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) antibody

Additional Information
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Alternative name Caspase-8 (P18)
Immunogen A synthetic peptide corresponding to a sequence at the middle region of human Caspase-8(P18), different to the related mouse sequence by a single amino acids
Format Affinity-purified
Isotype IgG  (Matching secondary antibodies)
Description Caspase 8 is a caspase protein. It most likely acts upon caspase 3. This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. The human CASP8 gene, whose product is also known as caspase 8 and FLICE, encodes an interleukin-1beta converting enzyme (ICE)-related cysteine protease that is activated by the engagement of several different death receptors. Caspase 8 is immediately recruited to the Fas receptor once it oligomerizes, and its protease activity is crucial for the apoptotic response generated by the resulting death-inducing signaling complex (DISC). This gene contains at least 11 exons spanning approximately 30kb on human chromosome band 2q33-34. This region of human chromosome 2 was previously reported as the location of the CASP10 gene, whose product is closely related to caspase 8. 1 Caspase-8 deficiency in humans is compatible with normal development and shows that caspase-8 has a postnatal role in immune activation of naive lymphocytes. 2

Application Details
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Application Notes Recommended Dilutions: WB 1ug/ml
Purification Immunogen affinity purified.
Buffer Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na 2 HPO 4 , 0.05mg Thimerosal, 0.05mg NaN 3 .
Storage Reconstitution: 0.2ml of distilled water will yield a concentration of 500ug/ml. At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for longer time.
Restrictions For Research Use only

Alternatives
Application Details Images Secondary Antibodies Variants back to top

Alternatives for antigen "Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8)", type "Antibodies"
Hosts Rabbit (68), Mouse (22), Rat (3)
Reactivities Human (81), Mouse (Murine) (39), Rat (Rattus) (36), Cow (Bovine) (25), Dog (Canine) (17), Chicken (16), Pig (Porcine) (16), Monkey (9), Chimpanzee (2), Rabbit (2), Horse (Equine) (1)
Applications Western Blotting (WB) (62), Flow Cytometry (FACS) (23), Immunofluorescence (IF) (23), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (20), ELISA (13), Immunoprecipitation (IP) (12), Enzyme Immunoassay (EIA) (9), Immunohistochemistry (IHC) (7), Immunohistochemistry (Frozen Sections) (IHC (fro)) (5), Dot Blot (Dot) (2), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (2), ELISA (Capture) (1), Immunocytochemistry (ICC) (1), Immunoelectron Microscopy (IEM) (1)
Conjugates Biotin (2), Alexa Flour 488 (1), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1), RBITC (1)
Epitopes C-Term (7), N-Term (6), active (3), Ab-347 (1), Cleaved-Asp384 (1), Middle (1), pSer347 (1), pTyr380 (1)