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Cyclin D1 (CCND1) antibody
| Antigen | Cyclin D1 (CCND1) |
| Synonyms |
BCL1, PRAD1, U21B31, D11S287E, cD1, Cyl-1, bcl-1, AI327039, DIP1, GCIP, Maid, SECC-8, SSEC-8, AU022347, cb161, cycd1, fb52e01, fc83a12, id:ibd1198, wu:fb52e01, wu:fc83a12, MGC109078, ccnd1b, MGC52909, ...
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| Clonality | Polyclonal |
| Host |
 Alternatives Rabbit |
| Reactivity |
Alternatives Human, Rat (Rattus), Mouse (Murine) |
| Application |
Alternatives Western Blotting (WB)
|
| Catalog no. | ABIN361205 |
| Quantity | 100ug (Variants) |
| Price | 283.33 $ Plus shipping costs $35.00 |
| Shipping to |
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| Availability | Ships within 5 to 7 Business Days |
Additional Information
| Alternative name | Cyclin D1 |
| Immunogen | A synthetic peptide corresponding to a sequence at the N-terminal of human Cyclin D1, different to the related mouse sequence by two amino acids |
| Format | Affinity-purified |
| Isotype | IgG (Matching secondary antibodies) |
| Description | Cyclin D1, also known as CCND1, is a human gene.The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclin D1 encodes the regulatory subunit of a holoenzyme that phosphorylates and inactivates the retinoblastoma protein and promotes progression through the G1-S phase of the cell cycle. Amplification or overexpression of cyclin D1 plays pivotal roles in the development of a subset of human cancers including parathyroid adenoma, breast cancer, colon cancer, lymphoma, melanoma, and prostate cancer. 1 The cyclin D1 gene is overexpressed in human breast cancers and is required for oncogene-induced tumorigenesis. 2 Brisken et al. (2003) found that prolactin (PRL, 176760) induced IGF2 (147470) mRNA and IGF2 induced cyclin D1 protein expression in mouse mammary epithelial cultures. And they also concluded that IGF2 is a mediator of prolactin-induced alveologenesis and that prolactin, IGF2, and cyclin D1 are components of a developmental pathway in mammary gland. 3 |
| Synonyms | BCL1, PRAD1, U21B31, D11S287E, cD1, Cyl-1, bcl-1, AI327039, DIP1, GCIP, Maid, SECC-8, SSEC-8, AU022347, cb161, cycd1, fb52e01, fc83a12, id:ibd1198, wu:fb52e01, wu:fc83a12, MGC109078, ccnd1b, MGC52909, MGC132138, ccnd1, MGC53090, bcl1, prad1, u21b31, MGC69515, d11s287e, CCND1, ccndbp1, MGC137744, ZHM, CCNDBP1, MGC133757, DKFZp468E2216, DKFZp469C1216, DKFZp469H0317 |
Application Details
| Application Notes | Recommended Dilutions: WB 1ug/ml |
| Purification | Immunogen affinity purified. |
| Buffer | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na 2 HPO 4 , 0.05mg Thimerosal, 0.05mg NaN 3 . |
| Storage | Reconstitution: 0.2ml of distilled water will yield a concentration of 500ug/ml. At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for longer time. |
| Research Area | Cancer, Cell Cycle |
| Restrictions | For Research Use only |
Alternatives
Alternatives for antigen "Cyclin D1 (CCND1)", type "Antibodies"
| Hosts | Rabbit (51), Mouse (27) |
| Reactivities | Human (67), Rat (Rattus) (31), Mouse (Murine) (27), Monkey (3), Dog (Canine) (2), Guinea Pig (2), Rabbit (2), Cow (Bovine) (1), Orang-Utan (1), Sheep (Ovine) (1) |
| Applications | Western Blotting (WB) (63), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (31), Immunoprecipitation (IP) (20), Immunohistochemistry (IHC) (14), Immunohistochemistry (Frozen Sections) (IHC (fro)) (13), ELISA (12), Enzyme Immunoassay (EIA) (9), Flow Cytometry (FACS) (8), Immunocytochemistry (ICC) (4), Immunofluorescence (IF) (4), ELISA (Detection) (3), Dot Blot (Dot) (1), Functional Studies (Func) (1) |
| Epitopes | C-Term (3), N-Term (2), Ab-286 (1), Center (1), S90 (1), pThr286 (1) |
