LXR alpha antibody
| Antigen |
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| Synonyms |
LXR, RLD1, Unr1, AU018371 |
| Clonality |
Polyclonal |
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Host
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Reactivity
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Application
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| Catalog no. |
ABIN361207 |
| Quantity |
100ug |
| Price |
283.33 $ Plus shipping costs $35.00
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| Shipping to |
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| Availability |
Ships within 5 to 7 Business Days |
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Alternative name
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LXRalpha
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Immunogen
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A synthetic peptide corresponding to a sequence at the C-terminal of human LXRα, identical to the related rat and mouse sequence
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Format
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Affinity-purified
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Isotype
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IgG (Matching secondary antibodies)
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Description
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LXRA is a tissue-specific cofactor that permits RXRA to function as a potent 9cRA receptor with a distinct target gene specificity. 1 It specifically interacts with RXRA in vivo to form a functional heterodimer in which RXRA is the ligand-binding subunit. Additionally, LXR activity is critical for physiologic lipid metabolism and transport. 2 LXRs are endogenous inhibitors of atherogenesis and are targets for therapeutic intervention in cardiovascular disease. Furthermore, LXRs and their ligands are negative regulators of macrophage inflammatory gene expression. 3 LXR is also found that as a transcriptional switch that integrates hepatic glucose metabolism and fatty acid synthesis. 4 The LXR-IDOL-LDLR axis defines a complementary pathway to sterol response element-binding proteins for sterol regulation of cholesterol uptake. 5
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Application Notes
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Recommended Dilutions: WB 1ug/ml
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Purification
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Immunogen affinity purified.
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Buffer
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Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na 2 HPO 4 , 0.05mg Thimerosal, 0.05mg NaN 3 .
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Storage
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Reconstitution: 0.2ml of distilled water will yield a concentration of 500ug/ml. At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for longer time.
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Restrictions
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For Research Use only
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Alternatives for antigen "LXR alpha", type "Antibodies"
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Hosts
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Rabbit (20)
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Reactivities
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Human (20), Mouse (Murine) (19), Rat (Rattus) (19), Dog (Canine) (17), Chicken (16), Cow (Bovine) (16), Horse (Equine) (15), Pig (Porcine) (1), Sheep (Ovine) (1)
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Applications
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Flow Cytometry (FACS) (18), Immunofluorescence (IF) (18), ELISA (3), Western Blotting (WB) (3), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (2), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (2), Immunoprecipitation (IP) (2), Immunoelectron Microscopy (IEM) (1)
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Conjugates
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Alexa Flour 488 (1), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1), RBITC (1)
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Alternatives 
