Keratin 17 (KRT17) antibody

Antigen: Keratin 17 (KRT17)

Synonyms: PC, K17, PC2, PCHC1, Krt1-17, MGC159887, Ka17, KRT17, krt16

Clonality: Monoclonal (83-13)

Host: Mouse

Reactivity: Mouse (Murine), Rat (Rattus)

Application: Western Blotting (WB)

Catalog no.: ABIN361253

Additional Information

Alternative name: CK17

Swiss-Prot: Q9QWL7 (mouse) Q04695 ( human)

Immunogen: This antibody is produced by immunizing mouse with a synthetic peptide (KLH-coupled) corresponding to near N-terminal residues of CK17.

Format: Liquid

Clone: 83-13

Description: "Cytokeratin 17 may play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial ""stem cells"". May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation Background"

Specificity: Cellular Localization: Cytoplasm. Molecular Weight: 48kDa

Application Details

Application Notes: Recommended Dilutions: WB: 1:500. Positive Control: Hela cells

Concentration: 0.5mg/ml

Buffer: 1*TBS (pH7.4), 0.5%BSA, 25%Glycerol. Preservative: 0.05% Sodium Azide.

Storage: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Restrictions: For Research Use only

Images

Western blot analysis on Hela using anti-CK17 monoclonal antibody. CK-17