Y Box Binding Protein 1 (YBX1) antibody (Biotin)

Antigen: Y Box Binding Protein 1 (YBX1)

Synonyms: Yb1, YB1, BP-8, CSDB, DBPB, YB-1, CSDA2, NSEP1, NSEP-1, MDR-NF1, MGC104858, MGC110976, MGC117250, ybx1, frgy1, nsep1, MGC52597, MGC130847

Clonality: Monoclonal (F-E2G5)

Host: Mouse

Reactivity: Human

Conjugate: Biotin

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Catalog no.: ABIN361278

Additional Information

Alternative name: YB-1

Gene ID: 4904

Immunogen: Recombinant YB-1

Format: Affinity-purified

Isotype: IgG2b

Clone: F-E2G5

Description: Members of Y-box binding protein family all contain a DNA binding domain, called the cold shock domain, comprising of 80 amino acids, which is highly conserved from prokaryotes to eukaryotes. Y-box binding protein-1 (YB-1) is a prototypic member of this family and was originally isolated as a DNA binding protein recognizing the Y-box sequence within the MHC class II gene promoter region. This box is found in the promoter region of several genes involved in positive regulation of cell cycle, such as proliferating cell nuclear antigen, DNA topoisomerase IIa, DNA-polymerase-alpha and cyclins. Consequently, YB-1 is thought to play crucial roles for cell proliferation and carcinogenesis. YB-1 has been reported to be a prognostic marker of breast cancer, ovarian cancer, lung cancer, thyroid cancer, and synovial sarcoma. These findings indicate the significance of YB-1 for the progression of malignant diseases. Alternative names: BP-8, CSDA2, CSDB, DBPB, MDR-NF1, MGC104858, MGC110976, MGC117250, NSEP-1, NSEP1, YB-1, YB1, YBX1, DNA-binding protein B, Y box-binding protein I, nuclease sensitive element binding protein 1.

Application Details

Concentration: 0,4 mg/ml

Buffer: PBS without any preservative

Storage: Store aliquots at +4°C. Do not freeze!

Research Area: Cancer

Restrictions: For Research Use only

Images

Invasive ductal breast cancer with abundant nuclear YB-1 expression using anti-YB-1 antibody (F-E2G5)

Publications

Publications: Dahl, En-Nia, Wiesmann et al.: "Nuclear detection of Y-box protein-1 (YB-1) closely associates with progesterone receptor negativity and is a strong adverse survival factor in human breast cancer." in: BMC cancer, Vol. 9, pp. 410, 2009 (PubMed).