Angiotensinogen (serpin Peptidase Inhibitor, Clade A, Member 8) (AGT) (405) antibody

Antigen: Angiotensinogen (serpin Peptidase Inhibitor, Clade A, Member 8) (AGT)

Synonyms: ANHU, FLJ92595, FLJ97926, SERPINA8, AngII, Aogen, AI265500, Serpina8, Ang, PAT, ANRT, MGC105326, wu:fb62f06, wu:fj87b02, zgc:111892, AGT, angt, ANGT

Epitope: 405

Clonality: Polyclonal

Host: Rabbit

Reactivity: Mouse (Murine), Rat (Rattus)

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Catalog no.: ABIN361281

Additional Information

Alternative name: Angiotensinogen (405)

Immunogen: Synthetic peptide of the C terminal part of Mouse Angiotensinogen ( IGDTNPRVGEVLNSIL)

Format: Affinity-purified

Description: Angiotensinogen is the precursor of angiotensin and is cleaved into angiotensin I and II in the renin-angiotensin system, and it has long been reported to play an important role in controlling blood pressure. In recent years interest related to the role of the renin-angiotensin system in arterial pressure control and the pathophysiology of hypertension has been shifting to its local role in various tissues. Among the studies urinary excretion of angiotensinogen in a rat model of angiotensin II (AII)-dependent hypertension has been reported to be a marker of the activity of the local intrarenal renin-angiotensin system. Intrarenal AII increases to an extent in AII-dependent hypertension that cannot be explained by the plasma AII equilibration alone, and two mechanisms, an increase in intracellular uptake of AII and an increase in intrarenal expression of angiotensinogen, have been proposed to explain it.

Specificity: Reacts with mouse and rat Angiotensinogen.

Application Details

Application Notes: This antibody can be used for immunohistochemistry with formalin fixed paraffin embedded tissues by several techniques such as Avidin Biotin Complex (ABC) Method. The optimal concentration is 1-5ug/mL, however, the concentration should be optimized by each laboratory.This antibody can be used for western blotting in concentration about 1ug /mL.

Purification: Purified with antigen peptide

Buffer: Lyophilized product from 1 % BSA in PBS containing 0.05 % NaN 3

Storage: Reconstitution: 1.0 mL deionized water will be added to the product (the conc. comes up 100ug /mL). Stability: Lyophilized product, 5 years at 2 – 8 °C. Solution: 2 years at 20 °C.

Restrictions: For Research Use only