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Rho-related GTP-binding protein antibody

RhO (pan) Reactivity: Cow WB, IHC Host: Mouse Monoclonal 1D4 unconjugated
Catalog No. ABIN361366
  • Target See all Rho-related GTP-binding protein (RhO (pan)) Antibodies
    Rho-related GTP-binding protein (RhO (pan))
    Reactivity
    • 20
    • 10
    • 10
    • 5
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cow
    Host
    • 25
    • 6
    • 1
    Mouse
    Clonality
    • 24
    • 8
    Monoclonal
    Conjugate
    • 23
    • 3
    • 2
    • 2
    • 1
    • 1
    This Rho-related GTP-binding protein antibody is un-conjugated
    Application
    • 24
    • 19
    • 14
    • 5
    • 5
    • 4
    • 4
    • 2
    Western Blotting (WB), Immunohistochemistry (IHC)
    Specificity
    Specific for the ~ 39k rhodopsin protein.
    Cross-Reactivity
    Amphibian, Mammalian
    Purification
    Protein G purified culture supernatant
    Immunogen
    Purified native bovine rhodopsin
    Clone
    1D4
    Isotype
    IgG1
    Top Product
    Discover our top product RhO (pan) Primary Antibody
  • Application Notes
    Recommended Dilution: WB: 1:1000 IHC: 1:100 Quality Control: Western blots performed on each lot.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.
    Storage
    -20 °C
  • Cho, Song, Shin, Kim: "Neonatal disease environment limits the efficacy of retinal transplantation in the LCA8 mouse model." in: BMC ophthalmology, Vol. 16, Issue 1, pp. 193, (2017) (PubMed).

    Kim, Park, Lee, Shin, Nickas, Kim, Cho: "Yap is essential for retinal progenitor cell cycle progression and RPE cell fate acquisition in the developing mouse eye." in: Developmental biology, Vol. 419, Issue 2, pp. 336-347, (2017) (PubMed).

  • Target
    Rho-related GTP-binding protein (RhO (pan))
    Alternative Name
    RHO (RhO (pan) Products)
    Target Type
    Chemical
    Background
    Rhodopsin is a photoreceptor protein found in retinal rods. It is a complex formed by the binding of retinaldehyde, the oxidized form of retinol, to the protein opsin and undergoes a series of complex reactions in response to visible light resulting in the transmission of nerve impulses to the brain. Mutation of the rhodopsin gene is a major contributor to various retinopathies such as retinitis pigmentosa. The disease-causing protein generally aggregates with ubiquitin in inclusion bodies, disrupts the intermediate filament network and impairs the ability of the cell to degrade non-functioning proteins which leads to photoreceptor apoptosis (Berson et al., 1991). Other mutations on rhodopsin lead to X-linked congenital stationary night blindness, mainly due to constitutive activation, when the mutations occur around the chromophore binding pocket of rhodopsin (Dryja et al.,1993). Several other pathological states relating to rhodopsin have been discovered including poor post-Golgi trafficking, dysregulative activation, rod outer segment instability and arrestin binding. Anti-Rhodopsin Immunohistochemical staining of mouse retinal section showing specific immunolabeling of the rhodopsin protein in the rod spherules. Photo courtesy of Mary Raven, University of California, Santa Barbara, CA.
    Molecular Weight
    '39 kDa
    Gene ID
    509933
    UniProt
    P02699
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