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Fractin A Marker of Apoptosis antibody
| Antigen | Fractin A Marker of Apoptosis |
| Clonality | Polyclonal |
| Host |
Rabbit |
| Reactivity |
Human, Rat (Rattus) |
| Application |
Western Blotting (WB), Immunohistochemistry (IHC)
|
| Catalog no. | ABIN361376 |
| Quantity | 100 µl |
| Price | 295.00 $ Plus shipping costs $35.00 |
| Shipping to |
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| Availability | Ships within 5 to 7 Business Days |
Additional Information
| Description | Fractin (fragment of actin) is a caspase-specific cleavage product of actin and serves as a novel marker of apoptosis-related events. The antibody has been shown to detect the processes and cell bodies of degenerating neurons and plaque-associated microglia in Alzheimer?s disease (Yang et al., 1998). It has recently been reported that Fractin may have a functional role in apoptotic signaling in oligodendrocytes (Schulz, R., et al., Glia, 2009, in press). Anti-Fractin Western blot of colchicine treated Sy5y cell lysate showing specific immunolabeling of the ~ 32k cleaved actin fragment (fractin). |
| Specificity | Specific for the ~ 32 kDa fractin protein in Western blots with no reactivity to intact actin. There is often a ladder of smaller bands in cells or culture or in vivo preparations due to further degradation by other proteases. |
