Norepinephrine Transporter (NET) antibody

Antigen: Norepinephrine Transporter (NET)

Synonyms: NET, NAT1, NET1, SLC6A5, NE-T, Slc6a5, Net, SLC6A2

Clonality: Monoclonal

Host: Mouse

Reactivity: Rat (Rattus), Mouse (Murine)

Application: Western Blotting (WB)

Catalog no.: ABIN361391

Additional Information

Alternative name: Norepinephrine Transporter

Isotype: IgG  (Matching secondary antibodies)

Description: Norepinephrine Transporter [NET] (or noradrenaline transporter (NAT)) is a monoamine transporter that transports the neurotransmitter noradrenaline from the synapse back to its vesicles for storage until later use. It also appears to transport the neurotransmitter dopamine in the same way, but to a lesser degree. Studies have shown a decrease in NET levels in the locus coeruleus in patients diagnosed with major depression (Klimek et al., 1997). Cocaine, amphetamines and many therapeutic antidepressants, such as the SNRIs (Serotonin-norepinephrine reuptake inhibitors) and the tricyclic antidepressants (TCAs) act to raise noradrenaline. Furthermore, deficits in the NET gene have been associated with ADHD (Kim et al., 2006). Anti-Norepinephrin Transporter Western blot of rat cortex homogenate showing specific immunolabeling of the ~ 55k norepinephrine transporter protein.

Specificity: Specific for the ~55kDa Norepinephrine Transporter in Western blots of mouse cortex homogenate. No reactivity with tissue or cells from NET knock-out mice.

Application Details

Application Notes: Recommended Dilution: WB: 1:2,000 Quality Control: Western blots performed on each lot.

Purification: Protein G purified culture supernatant.

Storage: Store at -20 °C, stable for 1 year

Restrictions: For Research Use only

Images

Western blots of rat cortex homogenate showing specific immunolabeling of the ~ 55k norepinephrine transporter protein.