Solute Carrier Family 8 (Sodium/calcium Exchanger), Member 1 (SLC8A1) antibody

Antigen: Solute Carrier Family 8 (Sodium/calcium Exchanger), Member 1 (SLC8A1)

Synonyms: NCX1, FLJ37694, FLJ43417, MGC119581, DKFZp779F0871, Ncx1, AI852629, AV344025, MGC90693, D930008O12Rik, Ncx, SLC8A1, ncx1n, DKFZp469I106

Clonality: Monoclonal (6H2)

Host: Mouse

Reactivity: Mammalian

Application: Western Blotting (WB)

Catalog no.: ABIN361392

Additional Information

Alternative name: Sodium Calcium Exchanger 1

Format: Affinity-purified

Isotype: IgG2b  (Matching secondary antibodies)

Clone: 6H2

Description: Ca2+ plays a critical role in intracellular signaling and thus regulation of calcium balance is critical for the maintenance of this signaling function. The plasma membrane Na+/Ca2+ (NaCX) exchangers mediate Na+-dependent Ca2+ efflux in a wide variety of cell types. NaCX can move Ca2+ either into or out of cells, depending on the net Na+, Ca2+, and K+ gradient across the membrane. In mammals, at least 5 distinct genes code for the exchangers: Three NaCX (NaCX-1, NaCX-2, and NaCX-3), and two in the NaCKX family (NaCKX-1 and NaCKX-2). NaCX-1 is most prominently expressed in the heart where it plays a major role in excitation-contraction coupling (Matsuoka et al., 1993). NACX-1 may also be a target for protection of the heart and brain from ischemia and reperfusion injury (Hagihara et al., 2005, Bano et al., 2005, Choi, 2005). Anti-Sodium Calcium Exchanger 1 Western blot of various tissues showing specific immunolabeling of the ~120k and ~160k NaCX-1 protein. Lane 1 - Brain, Lane 2 - Heart, Lane 3 - Kidney, Lane 4 - Lung, Lane 5 - Spleen.

Specificity: Specific for the ~120k and 160k Na+/Ca2+ exchanger 1 protein.

Application Details

Application Notes: Recommended Dilution: WB: 1:1000 Quality Control: Western blots performed on each lot.

Purification: Prepared by affinity purification using a protein G column.

Storage: Store at -20 °C, stable for 1 year

Restrictions: For Research Use only

Images

Western blots of various tissues showing specific immunolabeling of the ~120k and ~160k NaCX-1 protein. Lane 1 - Brain, Lane 2 - Heart, Lane 3 - Kidney, Lane 4 - Lung, Lane 5 - Spleen.