Transient Receptor Potential Cation Channel, Subfamily M, Member 7 (TRPM7) antibody

Antigen: Transient Receptor Potential Cation Channel, Subfamily M, Member 7 (TRPM7)

Synonyms: CHAK, CHAK1, LTRPC7, FLJ20117, FLJ25718, TRP-PLIK, Ltpr7, Ltrpc7, LTrpC-7, TRPPLIK, 2310022G15Rik, 4833414K03Rik, 5033407O22Rik, cb495, TRPM7, Chak, Trp-plik, chak, chak1, ltrpc7, trp-plik

Clonality: Polyclonal

Host: Rabbit

Reactivity: Mouse (Murine), Human

Application: ELISA

Catalog no.: ABIN361529

Additional Information

Alternative name: Trpm7

Gene ID: 58800

Immunogen: Partial peptide of Mouse Trpm7 (C-terminal region)

Format: Affinity-purified

Description: Function: Essential ion channel and serine/threonine-proteinkinase. Divalent cation channel permeableto calcium and magnesium. Hasa central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for thechannel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to themetabolic state of the cell. Phosphorylates annexin A1 (ANXA1) Tissue specificity: Found to be expressed in brain and skeletal muscle, with stronger signals in kidney, heart, liver and spleen Sequence similarities: In the C-terminal section, belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPKsubfamily. In the N-terminal section, belongs to the transient receptor family. LTrpC subfamily. Contains 1 alpha-type protein kinasedomain.

Application Details

Application Notes: ELISA: 1ug/ml

Concentration: 0.25 mg/ml

Purification: Antigen Affinity

Buffer: PBS [containing 2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat]

Storage: Store below -20 degrees Celsius

Research Area: Channels

Restrictions: For Research Use only

Publications

Publications: Hanano, Hara, Shi et al.: "Involvement of TRPM7 in cell growth as a spontaneously activated Ca2+ entry pathway in human retinoblastoma cells." in: Journal of pharmacological sciences, Vol. 95, Issue 4, pp. 403-19, 2004 (PubMed).

Numata, Shimizu, Okada: "TRPM7 is a stretch- and swelling-activated cation channel involved in volume regulation in human epithelial cells." in: American journal of physiology. Cell physiology, Vol. 292, Issue 1, pp. C460-7, 2007 (PubMed).