Histamine Receptor H4 (HRH4) antibody

Antigen: Histamine Receptor H4 (HRH4)

Synonyms: H4, H4R, BG26, HH4R, AXOR35, GPRv53, GPCR105, MGC133027, MGC130500, HRH4

Clonality: Monoclonal (2D5)

Host: Mouse

Reactivity: Human, Rat (Rattus)

Application: ELISA, Immunohistochemistry (IHC)

Catalog no.: ABIN361532

Additional Information

Alternative name: HRH4

Gene ID: 59340

Immunogen: Partial peptide of Human HRH4 (1st extracellular domain)

Format: Affinity-purified

Isotype: IgG1 kappa  (Matching secondary antibodies)

Clone: 2D5

Description: Function: The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant levelof constitutive activity (spontaneous activity in the absence of agonist) Tissue specificity: Expressed primarily in the bone marrow and eosinophils. Shows preferential distribution in cells of immunologicalrelevance such as T-cells, dendritic cells, monocytes, mast cells, neutrophils. Also expressed in a wide variety of peripheral tissues,including the heart, kidney, liver, lung, pancreas, skeletal muscle, prostate, small intestine, spleen, testis, colon, fetal liver and lymph node Sequence similarities: Belongs to the G-protein coupled receptor 1 family.

Application Details

Application Notes: ELISA: 1.0ug/ml. IHC: 5.0ug/ml

Concentration: 0.25 mg/ml

Purification: ProteinG Affinity Purified

Buffer: PBS [containing 2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat]

Storage: Store below -20 degrees Celsius

Research Area: Signaling

Restrictions: For Research Use only

Images

anti-Histamine Receptor H4 (HRH4) antibody

anti-Histamine Receptor H4 (HRH4) antibody (Image 2)

Publications

Publications: OReilly, Alpert, Jenkinson et al.: "Identification of a histamine H4 receptor on human eosinophils--role in eosinophil chemotaxis." in: Journal of receptor and signal transduction research, Vol. 22, Issue 1-4, pp. 431-48, 2002 (PubMed).

Gutzmer, Mommert, Gschwandtner et al.: "The histamine H4 receptor is functionally expressed on T(H)2 cells." in: The Journal of allergy and clinical immunology, Vol. 123, Issue 3, pp. 619-25, 2009 (PubMed).