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Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) antibody

Antigen

Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2)
Synonyms KNP3, EREG1, TRPC7, LTRPC2, NUDT9H, NUDT9L1, MGC133383, Trpm2-predicted, TRPM2, Trp7, Trrp7, C79133, 9830168K16Rik
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Mouse (Murine), Human, Rat (Rattus)
Application
Alternatives ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)
2 references available
Catalog no. ABIN361540
Quantity 25 ug  (0.25 mg/ml)  (Variants)
Price 865.64 $   Plus shipping costs $35.00
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Additional Information
Application Details Publications Alternatives Secondary Antibodies Variants back to top

Alternative name Trpm2
Gene ID 28240
Immunogen Partial peptide of Mouse Trpm2 (C-terminal region)
Format Affinity-purified
Description Function: Nonselective, voltage-independentcation channel mediating sodium and calcium ion influx in response to oxidative stress.Extracellularcalcium passes through the channel and acts from the intracellularside as a positive regulator in channel activation.Activatedby ADP-ribose, nicotinamide adenine dinucleotide (NAD+), reactive nitrogen species and arachidonic acid. Inactivated by intracellularATP. Confers susceptibility to cell death following oxidative stress. Has ADP-ribose pyrophosphatase activity Tissue specificity: Widely expressed, with highest levels in lung, spleen, eye and brain Sequence similarities: Belongs to the transient receptor family. LTrpC subfamily. Contains 1 nudix hydrolase domain.

Application Details
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Application Notes ELISA: 1ug/ml. WB: 1-5ug/ml. IHC: 5-10ug/ml. ICC: 1-5ug/ml.
Concentration 0.25 mg/ml
Purification Antigen Affinity
Buffer PBS [containing 2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat]
Storage Store below -20 degrees Celsius
Research Area Channels
Restrictions For Research Use only

Publications
Application Details Alternatives Secondary Antibodies Variants back to top

Publications Hara, Wakamori, Ishii et al.: "LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death." in: Molecular cell, Vol. 9, Issue 1, pp. 163-73, 2002 (PubMed).

Togashi, Hara, Tominaga et al.: "TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion." in: The EMBO journal, Vol. 25, Issue 9, pp. 1804-15, 2006 (PubMed).

Alternatives
Application Details Publications Secondary Antibodies Variants back to top

Alternatives for antigen "Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2)", type "Antibodies"
Hosts Rabbit (28), Sheep (2)
Reactivities Rat (Rattus) (24), Human (23), Mouse (Murine) (23), Horse (Equine) (16), Dog (Canine) (2), Pig (Porcine) (2), Chicken (1), Cow (Bovine) (1), Rabbit (1)
Applications Immunofluorescence (IF) (19), Western Blotting (WB) (12), Immunohistochemistry (IHC) (6), Immunoprecipitation (IP) (2), ELISA (1), Immunocytochemistry (ICC) (1), Immunoelectron Microscopy (IEM) (1)
Conjugates Alexa Flour 488 (1), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1), RBITC (1)
Epitopes C-Term (2), 3d extracellular loop (1), 4th cytoplasmic domain (1)