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Fc Fragment of IgE, Low Affinity II, Receptor For (CD23) (FCER2) antibody

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Antigen
  • BLAST-2
  • CD23
  • CD23A
  • CLEC4J
  • Fce2
  • FCE2
  • Fcer2
  • Fcer2a
  • IGEBF
  • Ly-42
Reactivity
Mouse (Murine), Human
278
146
24
Host
Mouse
208
106
88
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
53
53
20
12
8
5
5
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunofluorescence (IF), Immunoprecipitation (IP)
262
89
65
61
57
44
35
20
11
7
6
6
2
2
2
2
2
2
1
1
1
1
1
1
Supplier
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Immunogen Mouse Fcalpha/muR expressing cell line
Clone TX61
Isotype IgG1 kappa
Purification ProteinG Affinity Purified
Alternative Name Fcalpha/muR (FCER2 Antibody Abstract)
Background Function: Functions as a receptor for the Fc fragment of IgA and IgM. Binds IgA and IgM with high affinity and mediates theirendocytosis. May function in the immune response to microbes mediated by IgA and IgM Subcellular location: Cell membrane, Single-pass type I membrane protein Tissue specificity: Expressed in several tissues including thymus, spleen, liver, kidney, small and large intestine, testis and placenta.Expressed by oligodendrocytes, B cells and macrophages but not granulocytes, T cells or NK cells (at protein level) Sequence similarities: Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Gene ID 64435
Research Area Immunology
Application Notes IP: 5-10ug/ml. FACS: 0.5-1ug/ml. IF: 5.0-10ug/ml
Restrictions For Research Use only
Concentration 0.25 mg/ml
Buffer PBS [containing 2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat]
Preservative ProClin
Storage -20 °C
Background publications Cho, Usui, Honda, Tahara-Hanaoka, Shibuya, Shibuya: "Molecular characteristics of IgA and IgM Fc binding to the Fcalpha/muR." in: Biochemical and biophysical research communications, Vol. 345, Issue 1, pp. 474-8, 2006

Shibuya, Sakamoto, Shimizu, Shibuya, Osawa, Hiroyama, Eyre, Sutherland, Endo, Fujita, Miyabayashi, Sakano, Tsuji, Nakayama, Phillips, Lanier, Nakauchi: "Fc alpha/mu receptor mediates endocytosis of IgM-coated microbes." in: Nature immunology, Vol. 1, Issue 5, pp. 441-6, 2001