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Chloride Intracellular Channel 2 (CLIC2) antibody

Details for Product No. ABIN361555, Supplier: Log in to see
Antigen
  • zgc:92762
  • CLIC2
  • CLIC2b
  • MRXS32
  • XAP121
Reactivity
Human
32
17
15
2
2
2
1
Host
Mouse
24
8
Clonality
Polyclonal
Conjugate
Un-conjugated
1
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
21
11
7
3
1
Supplier
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Immunogen Recombinant protein of full length Human CLIC2
Purification Protein A purified
Alternative Name CLIC2 (CLIC2 Antibody Abstract)
Background Function: Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems tobe redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx Subcellular location: Cytoplasm. Membrane, Single-pass membrane protein Probable. Note: Exists both as soluble cytoplasmic protein andas membrane protein with probably a single transmembrane domain Tissue specificity: Detected in adult brain, heart, liver, lung, spleen, stomach and testis. Expressed in fetal liver and adult skeletal muscle Sequence similarities: Belongs to the chloride channel CLIC family. Contains 1 GST C-terminal domain.
Gene ID 1193
Research Area Transporters
Application Notes WB: 1ug/ml.
Restrictions For Research Use only
Concentration 1 mg/ml
Buffer PBS, pH 7.2
Storage -20 °C
Background publications Ross, Grafham, Coffey et al.: "The DNA sequence of the human X chromosome. ..." in: Nature, Vol. 434, Issue 7031, pp. 325-37, 2005 (PubMed).

Gerhard, Wagner, Feingold et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ..." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).

Heiss, Poustka: "Genomic structure of a novel chloride channel gene, CLIC2, in Xq28." in: Genomics, Vol. 45, Issue 1, pp. 224-8, 1997 (PubMed).