Chloride Intracellular Channel 2 (CLIC2) antibody

Antigen: Chloride Intracellular Channel 2 (CLIC2)

Synonyms: CLIC2b, XAP121, MGC108828, CLIC2, zgc:92762, MGC148419

Clonality: Polyclonal

Host: Mouse

Reactivity: Human

Application: Western Blotting (WB)

Catalog no.: ABIN361555

Additional Information

Alternative name: CLIC2

Gene ID: 1193

Immunogen: Recombinant protein of full length Human CLIC2

Format: Affinity-purified

Description: Function: Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems tobe redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx Subcellular location: Cytoplasm. Membrane, Single-pass membrane protein Probable. Note: Exists both as soluble cytoplasmic protein andas membrane protein with probably a single transmembrane domain Tissue specificity: Detected in adult brain, heart, liver, lung, spleen, stomach and testis. Expressed in fetal liver and adult skeletal muscle Sequence similarities: Belongs to the chloride channel CLIC family. Contains 1 GST C-terminal domain.

Application Details

Application Notes: WB: 1ug/ml.

Concentration: 1 mg/ml

Purification: Protein A purified

Buffer: PBS, pH 7.2

Storage: Store below -20 degrees Celsius

Research Area: Transporters

Restrictions: For Research Use only

Images

CLIC2 transfected 293T cell lysate 0 0

CLIC2 transfected 293T cell lysate 0 0

Publications

Publications: Heiss, Poustka: "Genomic structure of a novel chloride channel gene, CLIC2, in Xq28." in: Genomics, Vol. 45, Issue 1, pp. 224-8, 1997 (PubMed).

Gerhard, Wagner, Feingold et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).

Ross, Grafham, Coffey et al.: "The DNA sequence of the human X chromosome." in: Nature, Vol. 434, Issue 7031, pp. 325-37, 2005 (PubMed).