Regulator of G-Protein Signaling 7 (RGS7) antibody

Antigen: Regulator of G-Protein Signaling 7 (RGS7)

Synonyms: RGS7, MGC137820, zgc:92793

Clonality: Polyclonal

Host: Mouse

Reactivity: Human, Rat (Rattus)

Application: Western Blotting (WB), Flow Cytometry (FACS)

Catalog no.: ABIN361562

Additional Information

Alternative name: RGS7

Gene ID: 6000

Immunogen: Recombinant protein of full length Human RGS7

Format: Affinity-purified

Description: Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactiveGDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/GNG5 dimer. May play a role in synaptic vesicle exocytosis.May play important role in the rapid regulation of neuronal excitability and the cellular responses to short-lived stimulations Sequence similarities: Contains 1 DEP domain. Contains 1 G protein gamma domain. Contains 1 RGS domain.

Application Details

Application Notes: WB: 1ug/ml. FACS: 1ug/ml

Concentration: 0.5 mg/ml

Purification: Protein A purified

Buffer: PBS, pH 7.2

Storage: Store below -20 degrees Celsius

Research Area: Signaling

Restrictions: For Research Use only

Images

rat brain tissue lysate RGS7 transfected 293T cell lysate

rat brain tissue lysate RGS7 transfected 293T cell lysate

RGS7 expressing 293 cells. Negative control Transfectant

Publications

Koelle, Horvitz: "EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins." in: Cell, Vol. 84, Issue 1, pp. 115-25, 1996 (PubMed).

Kim, Arnould, Sellin et al.: "Interaction between RGS7 and polycystin." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 11, pp. 6371-6, 1999 (PubMed).

Snow, Betts, Mangion et al.: "Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 11, pp. 6489-94, 1999 (PubMed).