T-Cell Lymphoma Invasion and Metastasis 2 (TIAM2) antibody

Antigen: T-Cell Lymphoma Invasion and Metastasis 2 (TIAM2)

Synonyms: STEF, FLJ41865, mKIAA2016, 3000002F19Rik, TIAM2

Clonality: Polyclonal

Host: Mouse

Reactivity: Human, Rat (Rattus)

Application: Western Blotting (WB), Flow Cytometry (FACS)

Catalog no.: ABIN361569

Additional Information

Alternative name: TIAM2

Gene ID: 26230

Immunogen: Recombinant protein of full length Human TIAM2

Format: Affinity-purified

Description: Function: Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediatesextracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of thegrowth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex Subcellular location: Cytoplasm. Cell projection > lamellipodium. Cell projection > filopodium. Cell projection > growth cone. Note: Localizesto the plasma membrane in neurites Tissue specificity: Expressed in the occipital, frontal and temporal lobes, cerebellum, putamen and testis Sequence similarities: Belongs to the TIAM family. Contains 1 DH (DBL-homology) domain. Contains 1 PDZ (DHR) domain. Contains 2 PHdomains. Contains 1 RBD (Ras-binding) domain.

Application Details

Application Notes: WB: 1ug/ml. FACS: 1ug/ml

Concentration: 0.45 mg/ml

Purification: Protein A purified

Buffer: PBS, pH 7.2

Storage: Store below -20 degrees Celsius

Research Area: Cancer

Restrictions: For Research Use only

Images

TIAM2 transfected 293T cell lysate

TIAM2 transfected 293T cell lysate

TIAM2 expressing 293 cells 0

Publications

Chiu, Leng, Martin et al.: "Cloning and characterization of T-cell lymphoma invasion and metastasis 2 (TIAM2), a novel guanine nucleotide exchange factor related to TIAM1." in: Genomics, Vol. 61, Issue 1, pp. 66-73, 1999 (PubMed).

Gerhard, Wagner, Feingold et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).

Bechtel, Rosenfelder, Duda et al.: "The full-ORF clone resource of the German cDNA Consortium." in: BMC genomics, Vol. 8, pp. 399, 2008 (PubMed).