T-Cell Lymphoma Invasion and Metastasis 2 (TIAM2) antibody

Details for Product No. ABIN361569
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Antigen
Synonyms TIAM2, 3000002F19Rik, STEF, mKIAA2016, TIAM-2
Reactivity
Human, Rat (Rattus)
(21), (3), (2), (1)
Host
Mouse
(13), (6), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Flow Cytometry (FACS)
(18), (15), (4), (2), (2), (1), (1), (1)
Pubmed 3 references available
Quantity 50 μg
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Availability Will be delivered in 9 to 11 Business Days
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Catalog No. ABIN361569
627.13 $
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Immunogen Recombinant protein of full length Human TIAM2
Purification Protein A purified
Alternative Name TIAM2
Background Function: Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediatesextracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of thegrowth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex Subcellular location: Cytoplasm. Cell projection > lamellipodium. Cell projection > filopodium. Cell projection > growth cone. Note: Localizesto the plasma membrane in neurites Tissue specificity: Expressed in the occipital, frontal and temporal lobes, cerebellum, putamen and testis Sequence similarities: Belongs to the TIAM family. Contains 1 DH (DBL-homology) domain. Contains 1 PDZ (DHR) domain. Contains 2 PHdomains. Contains 1 RBD (Ras-binding) domain.
Gene ID 26230
Research Area Cancer
Application Notes WB: 1ug/ml. FACS: 1ug/ml
Restrictions For Research Use only
Concentration 0.45 mg/ml
Buffer PBS, pH 7.2
Storage -20 °C
General Chiu, Leng, Martin et al.: "Cloning and characterization of T-cell lymphoma invasion and metastasis 2 (TIAM2), a novel guanine nucleotide exchange factor related to TIAM1." in: Genomics, Vol. 61, Issue 1, pp. 66-73, 1999 (PubMed).

Gerhard, Wagner, Feingold et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ..." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).

Bechtel, Rosenfelder, Duda et al.: "The full-ORF clone resource of the German cDNA Consortium." in: BMC genomics, Vol. 8, pp. 399, 2008 (PubMed).

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