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SMAD, Mothers Against DPP Homolog 6 (SMAD6) antibody

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Synonyms madh6, madh7, Xsmad6, hst17432, AOVD2, HsT17432, MADH6, MADH7, Madh6, b2b390Clo, Smad6-like, smad6, wu:fb22g05
(118), (34), (11), (2), (2), (1), (1), (1), (1)
(95), (47)
(4), (4), (4), (4), (4), (4)
Flow Cytometry (FACS), Western Blotting (WB)
(129), (80), (29), (26), (22), (6), (4), (3), (2), (2)
Pubmed 3 references available
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Quantity 50 μg
Shipping to United States ( )
Availability Will be delivered in 9 to 11 Business Days
Immunogen Recombinant protein of full length Human SMAD6
Purification Protein A purified
Alternative Name SMAD6 (SMAD6 Antibody Abstract)
Background Function: Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members, has been shown toinhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1.SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Binds to regulatory elements in target promoter regions Subcellular location: Nucleus Tissue specificity: Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue Sequence similarities: Belongs to the dwarfin/SMAD family. Contains 1 MH1 (MAD homology 1) domain. Contains 1 MH2 (MAD homology2) domain.
Gene ID 4091
Research Area Signaling
Application Notes WB: 1ug/ml. FACS: 1ug/ml
Restrictions For Research Use only
Concentration 0.46 mg/ml
Buffer PBS, pH 7.2
Storage -20 °C
Background publications Afrakhte, Moruen, Jossan et al.: "Induction of inhibitory Smad6 and Smad7 mRNA by TGF-beta family members." in: Biochemical and biophysical research communications, Vol. 249, Issue 2, pp. 505-11, 1998 (PubMed).

Hata, Lagna, Massaguue et al.: "Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor." in: Genes & development, Vol. 12, Issue 2, pp. 186-97, 1998 (PubMed).

Riggins, Thiagalingam, Rozenblum et al.: "Mad-related genes in the human." in: Nature genetics, Vol. 13, Issue 3, pp. 347-9, 1996 (PubMed).

Catalog No. ABIN361570
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