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SMAD, Mothers Against DPP Homolog 6 (SMAD6) antibody

Antigen

SMAD, Mothers Against DPP Homolog 6 (SMAD6)
Synonyms MADH6, MADH7, HsT17432, madh6, madh7, Xsmad6, hst17432
Clonality Polyclonal
Host
Alternatives

Mouse
Reactivity
Alternatives

Human
Application
Alternatives Western Blotting (WB), Flow Cytometry (FACS)
3 references available
Catalog no. ABIN361570
Quantity 50 ug  (0.46 mg/ml)
Price 619.19 $   Plus shipping costs $35.00
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anti-SMAD, Mothers Against DPP Homolog 6 (SMAD6) antibody

anti-SMAD, Mothers Against DPP Homolog 6 (SMAD6) antibody (2)

Additional Information
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Alternative name SMAD6
Gene ID 4091
Immunogen Recombinant protein of full length Human SMAD6
Format Affinity-purified
Description Function: Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members, has been shown toinhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1.SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Binds to regulatory elements in target promoter regions Subcellular location: Nucleus Tissue specificity: Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue Sequence similarities: Belongs to the dwarfin/SMAD family. Contains 1 MH1 (MAD homology 1) domain. Contains 1 MH2 (MAD homology2) domain.

Application Details
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Application Notes WB: 1ug/ml. FACS: 1ug/ml
Concentration 0.46 mg/ml
Purification Protein A purified
Buffer PBS, pH 7.2
Storage Store below -20 degrees Celsius
Research Area Signaling
Restrictions For Research Use only

Publications
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Publications Riggins, Thiagalingam, Rozenblum et al.: "Mad-related genes in the human." in: Nature genetics, Vol. 13, Issue 3, pp. 347-9, 1996 (PubMed).

Hata, Lagna, Massaguue et al.: "Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor." in: Genes & development, Vol. 12, Issue 2, pp. 186-97, 1998 (PubMed).

Afrakhte, Moruen, Jossan et al.: "Induction of inhibitory Smad6 and Smad7 mRNA by TGF-beta family members." in: Biochemical and biophysical research communications, Vol. 249, Issue 2, pp. 505-11, 1998 (PubMed).

Alternatives
Application Details Publications Images Secondary Antibodies back to top

Alternatives for antigen "SMAD, Mothers Against DPP Homolog 6 (SMAD6)", type "Antibodies"
Hosts Mouse (21), Rabbit (8)
Reactivities Human (29), Mouse (Murine) (2), Rat (Rattus) (2), Monkey (1)
Applications Western Blotting (WB) (28), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (13), Enzyme Immunoassay (EIA) (12), ELISA (7), ELISA (Detection) (3), Flow Cytometry (FACS) (2), Immunohistochemistry (IHC) (2)