You are viewing an incomplete version of our website. Please click to reload the website as full version.

SMAD, Mothers Against DPP Homolog 6 (SMAD6) antibody

Details for Product No. ABIN361570, Supplier: Login to see
Antigen
  • madh6
  • madh7
  • Xsmad6
  • hst17432
  • AOVD2
  • HsT17432
  • MADH6
  • MADH7
  • Madh6
  • b2b390Clo
  • Smad6-like
  • smad6
  • wu:fb22g05
Reactivity
Human
118
34
11
2
2
1
1
1
1
Host
Mouse
95
47
Clonality
Polyclonal
Conjugate
Un-conjugated
4
4
4
4
4
4
Application
Flow Cytometry (FACS), Western Blotting (WB)
129
80
29
26
22
6
4
3
2
2
Supplier
Login to see
Supplier Product No.
Login to see
Request

Showcase your results, aid the scientific community, and receive a full refund.

Contribute a validation

Learn more

Immunogen Recombinant protein of full length Human SMAD6
Purification Protein A purified
Alternative Name SMAD6 (SMAD6 Antibody Abstract)
Background Function: Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members, has been shown toinhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1.SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Binds to regulatory elements in target promoter regions Subcellular location: Nucleus Tissue specificity: Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue Sequence similarities: Belongs to the dwarfin/SMAD family. Contains 1 MH1 (MAD homology 1) domain. Contains 1 MH2 (MAD homology2) domain.
Gene ID 4091
Research Area Signaling
Pathways
Application Notes WB: 1ug/ml. FACS: 1ug/ml
Restrictions For Research Use only
Concentration 0.46 mg/ml
Buffer PBS, pH 7.2
Storage -20 °C
Background publications Afrakhte, Moruen, Jossan et al.: "Induction of inhibitory Smad6 and Smad7 mRNA by TGF-beta family members." in: Biochemical and biophysical research communications, Vol. 249, Issue 2, pp. 505-11, 1998 (PubMed).

Hata, Lagna, Massaguue et al.: "Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor." in: Genes & development, Vol. 12, Issue 2, pp. 186-97, 1998 (PubMed).

Riggins, Thiagalingam, Rozenblum et al.: "Mad-related genes in the human." in: Nature genetics, Vol. 13, Issue 3, pp. 347-9, 1996 (PubMed).