SMAD, Mothers Against DPP Homolog 6 (SMAD6) antibody

Details for Product No. ABIN361570
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Antigen
Synonyms madh6, smad6, wu:fb22g05, Smad6-like, AOVD2, HsT17432, MADH6, MADH7, Madh6, b2b390Clo, madh7, Xsmad6, hst17432
Reactivity
Human
(63), (12), (4), (2), (1), (1), (1), (1)
Host
Mouse
(34), (31)
Clonality
Polyclonal
Application
Western Blotting (WB), Flow Cytometry (FACS)
(64), (34), (23), (9), (7), (4), (3), (2), (2), (1)
Pubmed 3 references available
Catalog no. ABIN361570
Quantity 50 µg
Price
627.13 $   Plus shipping costs $45.00
Shipping to United States (Change)
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Immunogen Recombinant protein of full length Human SMAD6
Purification Protein A purified
Alternative Name SMAD6
Background Function: Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members, has been shown toinhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1.SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Binds to regulatory elements in target promoter regions Subcellular location: Nucleus Tissue specificity: Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue Sequence similarities: Belongs to the dwarfin/SMAD family. Contains 1 MH1 (MAD homology 1) domain. Contains 1 MH2 (MAD homology2) domain.
Gene ID 4091
Research Area Signaling
Application Notes WB: 1ug/ml. FACS: 1ug/ml
Restrictions For Research Use only
Concentration 0.46 mg/ml
Buffer PBS, pH 7.2
Storage -20 °C
General Riggins, Thiagalingam, Rozenblum et al.: "Mad-related genes in the human." in: Nature genetics, Vol. 13, Issue 3, pp. 347-9, 1996 (PubMed).

Hata, Lagna, Massaguue et al.: "Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor." in: Genes & development, Vol. 12, Issue 2, pp. 186-97, 1998 (PubMed).

Afrakhte, Moruen, Jossan et al.: "Induction of inhibitory Smad6 and Smad7 mRNA by TGF-beta family members." in: Biochemical and biophysical research communications, Vol. 249, Issue 2, pp. 505-11, 1998 (PubMed).

Hosts (34), (31)
Reactivities (63), (12), (4), (2), (1), (1), (1), (1)
Applications (64), (34), (23), (9), (7), (4), (3), (2), (2), (1)
Epitopes (8), (7), (5), (4), (4), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1)
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