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SMAD, Mothers Against DPP Homolog 6 (SMAD6) antibody

Antigen

SMAD, Mothers Against DPP Homolog 6 (SMAD6)
Synonyms MADH6, MADH7, HsT17432, madh6, madh7, Xsmad6, hst17432
Clonality Polyclonal
Host
Alternatives

Mouse
Reactivity
Alternatives

Human
Application
Alternatives Western Blotting (WB), Flow Cytometry (FACS)
3 references available
Catalog no. ABIN361570
Quantity 50 ug  (0.46 mg/ml)
Price 627.13 $   Plus shipping costs $45.00
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anti-SMAD, Mothers Against DPP Homolog 6 (SMAD6) antibody

anti-SMAD, Mothers Against DPP Homolog 6 (SMAD6) antibody (2)

Additional Information
Application Details Publications Images Alternatives back to top

Alternative name SMAD6
Gene ID 4091
Immunogen Recombinant protein of full length Human SMAD6
Format Affinity-purified
Description Function: Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members, has been shown toinhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1.SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Binds to regulatory elements in target promoter regions Subcellular location: Nucleus Tissue specificity: Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue Sequence similarities: Belongs to the dwarfin/SMAD family. Contains 1 MH1 (MAD homology 1) domain. Contains 1 MH2 (MAD homology2) domain.

Application Details
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Application Notes WB: 1ug/ml. FACS: 1ug/ml
Concentration 0.46 mg/ml
Purification Protein A purified
Buffer PBS, pH 7.2
Storage Store below -20 degrees Celsius
Research Area Signaling
Restrictions For Research Use only

Publications
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Riggins, Thiagalingam, Rozenblum et al.: "Mad-related genes in the human." in: Nature genetics, Vol. 13, Issue 3, pp. 347-9, 1996 (PubMed).

Hata, Lagna, Massaguue et al.: "Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor." in: Genes & development, Vol. 12, Issue 2, pp. 186-97, 1998 (PubMed).

Afrakhte, Moruen, Jossan et al.: "Induction of inhibitory Smad6 and Smad7 mRNA by TGF-beta family members." in: Biochemical and biophysical research communications, Vol. 249, Issue 2, pp. 505-11, 1998 (PubMed).

Alternatives
Application Details Publications Images back to top

Alternatives for antigen "SMAD, Mothers Against DPP Homolog 6 (SMAD6)", type "Antibodies"
Hosts Mouse (12), Rabbit (12)
Reactivities Human (24), Chicken (1), Cow (Bovine) (1), Dog (Canine) (1), Mouse (Murine) (1), Rat (Rattus) (1), Zebrafish (1)
Applications Western Blotting (WB) (23), ELISA (14), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (11), Immunohistochemistry (IHC) (4)
Epitopes N-Term (2), AA 372-388,AA 85-99, (1), AA 85-99 (1), C-Term (1), Center (1)