SMAD, Mothers Against DPP Homolog 6 (SMAD6) antibody

Details for Product No. ABIN361570
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Antigen
Synonyms madh6, madh7, Xsmad6, hst17432, AOVD2, HsT17432, MADH6, MADH7, Madh6, b2b390Clo, Smad6-like, smad6, wu:fb22g05
Reactivity
Human
(106), (31), (8), (2), (2), (1), (1), (1), (1)
Host
Mouse
(88), (40)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (4), (4), (4), (4), (4)
Application
Western Blotting (WB), Flow Cytometry (FACS)
(121), (70), (27), (23), (21), (7), (6), (6), (6), (4), (2), (2)
Pubmed 3 references available
Quantity 50 μg
Shipping to United States ( )
Availability Will be delivered in 9 to 11 Business Days
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Immunogen Recombinant protein of full length Human SMAD6
Purification Protein A purified
Alternative Name SMAD6 (SMAD6 Antibody Abstract)
Background Function: Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members, has been shown toinhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1.SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Binds to regulatory elements in target promoter regions Subcellular location: Nucleus Tissue specificity: Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue Sequence similarities: Belongs to the dwarfin/SMAD family. Contains 1 MH1 (MAD homology 1) domain. Contains 1 MH2 (MAD homology2) domain.
Gene ID 4091
Research Area Signaling
Application Notes WB: 1ug/ml. FACS: 1ug/ml
Restrictions For Research Use only
Concentration 0.46 mg/ml
Buffer PBS, pH 7.2
Storage -20 °C
General Afrakhte, Moruen, Jossan et al.: "Induction of inhibitory Smad6 and Smad7 mRNA by TGF-beta family members." in: Biochemical and biophysical research communications, Vol. 249, Issue 2, pp. 505-11, 1998 (PubMed).

Hata, Lagna, Massaguue et al.: "Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor." in: Genes & development, Vol. 12, Issue 2, pp. 186-97, 1998 (PubMed).

Riggins, Thiagalingam, Rozenblum et al.: "Mad-related genes in the human." in: Nature genetics, Vol. 13, Issue 3, pp. 347-9, 1996 (PubMed).

Validation Images
Catalog No. ABIN361570
496.41 $
Plus shipping costs $45.00
Quantity
Price
50 μg
496.41 $

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