HFE antibody (Hemochromatosis)

Details for Product anti-HFE Antibody No. ABIN361571, Supplier: Log in to see
Antigen
  • HFE1
  • HH
  • HLA-H
  • MVCD7
  • TFQTL2
  • MR2
  • hemochromatosis
  • HFE
  • Hfe
Alternatives
anti-Human HFE antibody for Immunohistochemistry
Reactivity
Human
74
25
22
2
2
2
2
1
1
1
1
Host
Mouse
60
17
Clonality
Polyclonal
Conjugate
This HFE antibody is un-conjugated
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Western Blotting (WB)
62
24
15
14
13
10
4
4
2
1
1
Options
Supplier
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Immunogen Recombinant protein of full length Human HFE
Purification Protein A purified
Alternative Name HFE (HFE Antibody Abstract)
Background Function: Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin Subcellular location: Membrane, Single-pass type I membrane protein Tissue specificity: In all tissues tested except brain Sequence similarities: Belongs to the MHC class I family. Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
Gene ID 3077
Pathways Transition Metal Ion Homeostasis, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
Application Notes WB: 1ug/ml. FACS: 1ug/ml
Restrictions For Research Use only
Concentration 0.44 mg/ml
Buffer PBS, pH 7.2
Storage -20 °C
Background publications Albig, Drabent, Burmester, Bode, Doenecke: "The haemochromatosis candidate gene HFE (HLA-H) of man and mouse is located in syntenic regions within the histone gene cluster." in: Journal of cellular biochemistry, Vol. 69, Issue 2, pp. 117-26, 1998 (PubMed).

Ruddy, Kronmal, Lee, Mintier, Quintana, Domingo, Meyer, Irrinki, McClelland, Fullan, Mapa, Moore, Thomas, Loeb, Harmon, Tsuchihashi, Wolff, Schatzman, Feder: "A 1.1-Mb transcript map of the hereditary hemochromatosis locus." in: Genome research, Vol. 7, Issue 5, pp. 441-56, 1997 (PubMed).

Feder, Gnirke, Thomas, Tsuchihashi, Ruddy, Basava, Dormishian, Domingo, Ellis, Fullan, Hinton, Jones, Kimmel, Kronmal, Lauer, Lee, Loeb, Mapa, McClelland, Meyer, Mintier, Moeller, Moore, Morikang, Prass, Quintana, Starnes, Schatzman, Brunke, Drayna, Risch: "A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis." in: Nature genetics, Vol. 13, Issue 4, pp. 399-408, 1996 (PubMed).

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