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Hemochromatosis (HFE) antibody

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Synonyms HFE1, HH, HLA-H, MVCD7, TFQTL2, MR2
(62), (20), (16), (1)
(52), (13)
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Flow Cytometry (FACS), Western Blotting (WB)
(50), (22), (13), (13), (11), (6), (4), (3), (1), (1)
Pubmed 3 references available
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Quantity 50 μg
Shipping to United States ( )
Availability Will be delivered in 9 to 11 Business Days
Immunogen Recombinant protein of full length Human HFE
Purification Protein A purified
Alternative Name HFE (HFE Antibody Abstract)
Background Function: Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin Subcellular location: Membrane, Single-pass type I membrane protein Tissue specificity: In all tissues tested except brain Sequence similarities: Belongs to the MHC class I family. Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
Gene ID 3077
Application Notes WB: 1ug/ml. FACS: 1ug/ml
Restrictions For Research Use only
Concentration 0.44 mg/ml
Buffer PBS, pH 7.2
Storage -20 °C
Background publications Albig, Drabent, Burmester et al.: "The haemochromatosis candidate gene HFE (HLA-H) of man and mouse is located in syntenic regions within the histone gene cluster." in: Journal of cellular biochemistry, Vol. 69, Issue 2, pp. 117-26, 1998 (PubMed).

Ruddy, Kronmal, Lee et al.: "A 1.1-Mb transcript map of the hereditary hemochromatosis locus." in: Genome research, Vol. 7, Issue 5, pp. 441-56, 1997 (PubMed).

Feder, Gnirke, Thomas et al.: "A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis." in: Nature genetics, Vol. 13, Issue 4, pp. 399-408, 1996 (PubMed).

Catalog No. ABIN361571
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