Hemochromatosis (HFE) antibody

Antigen: Hemochromatosis (HFE)

Synonyms: HH, HFE1, HLA-H, MVCD7, MGC103790, dJ221C16.10.1

Clonality: Polyclonal

Host: Mouse

Reactivity: Human

Application: Western Blotting (WB), Flow Cytometry (FACS)

Catalog no.: ABIN361571

Additional Information

Alternative name: HFE

Gene ID: 3077

Immunogen: Recombinant protein of full length Human HFE

Format: Affinity-purified

Description: Function: Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin Subcellular location: Membrane, Single-pass type I membrane protein Tissue specificity: In all tissues tested except brain Sequence similarities: Belongs to the MHC class I family. Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Application Details

Application Notes: WB: 1ug/ml. FACS: 1ug/ml

Concentration: 0.44 mg/ml

Purification: Protein A purified

Buffer: PBS, pH 7.2

Storage: Store below -20 degrees Celsius

Restrictions: For Research Use only

Images

HFE transfected 293T cell lysate

HFE transfected 293T cell lysate

HFE expressing 293 cells 0

Publications

Publications: Feder, Gnirke, Thomas et al.: "A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis." in: Nature genetics, Vol. 13, Issue 4, pp. 399-408, 1996 (PubMed).

Ruddy, Kronmal, Lee et al.: "A 1.1-Mb transcript map of the hereditary hemochromatosis locus." in: Genome research, Vol. 7, Issue 5, pp. 441-56, 1997 (PubMed).

Albig, Drabent, Burmester et al.: "The haemochromatosis candidate gene HFE (HLA-H) of man and mouse is located in syntenic regions within the histone gene cluster." in: Journal of cellular biochemistry, Vol. 69, Issue 2, pp. 117-26, 1998 (PubMed).