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Hemochromatosis (HFE) antibody

Details for Product No. ABIN361571, Supplier: Log in to see
Antigen
  • HFE1
  • HH
  • HLA-H
  • MVCD7
  • TFQTL2
  • MR2
Reactivity
Human
60
20
16
1
Host
Mouse
50
13
Clonality
Polyclonal
Conjugate
Un-conjugated
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Western Blotting (WB)
48
21
13
12
11
5
4
3
1
1
Supplier
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Immunogen Recombinant protein of full length Human HFE
Purification Protein A purified
Alternative Name HFE (HFE Antibody Abstract)
Background Function: Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin Subcellular location: Membrane, Single-pass type I membrane protein Tissue specificity: In all tissues tested except brain Sequence similarities: Belongs to the MHC class I family. Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
Gene ID 3077
Pathways
Application Notes WB: 1ug/ml. FACS: 1ug/ml
Restrictions For Research Use only
Concentration 0.44 mg/ml
Buffer PBS, pH 7.2
Storage -20 °C
Background publications Albig, Drabent, Burmester et al.: "The haemochromatosis candidate gene HFE (HLA-H) of man and mouse is located in syntenic regions within the histone gene cluster." in: Journal of cellular biochemistry, Vol. 69, Issue 2, pp. 117-26, 1998 (PubMed).

Ruddy, Kronmal, Lee et al.: "A 1.1-Mb transcript map of the hereditary hemochromatosis locus." in: Genome research, Vol. 7, Issue 5, pp. 441-56, 1997 (PubMed).

Feder, Gnirke, Thomas et al.: "A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis." in: Nature genetics, Vol. 13, Issue 4, pp. 399-408, 1996 (PubMed).