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Formyl Peptide Receptor 2 (FPR2) antibody

Details for Product No. ABIN361594, Supplier: Login to see
Antigen
  • FPRL1
  • FPR2
  • FMLP-R-I
  • ALXR
  • FMLP-R-II
  • FMLPX
  • FPR2A
  • FPRH1
  • FPRH2
  • HM63
  • LXA4R
  • E330010I07Rik
  • Fpr-rs2
  • Fprl1
  • ALX
  • Fpr-rs1
  • Fpr-s1
  • LXA4-R
  • Lxa4r
Reactivity
Human
90
18
18
Host
Mouse
43
30
19
Clonality
Polyclonal
Conjugate
Un-conjugated
3
3
3
3
2
2
2
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Western Blotting (WB)
42
37
12
12
11
5
4
4
3
1
1
Supplier
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Immunogen Recombinant protein of full length Human FPRL1
Purification Protein A purified
Alternative Name FPRL1 (FPR2 Antibody Abstract)
Background Function: Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to thereceptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium secondmessenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatorysignals such as LTB4 (leukotriene B4) Subcellular location: Cell membrane, Multi-pass membrane protein Tissue specificity: Expressed abundantly in the lung and neutrophils. Also found in the spleen and testis Sequence similarities: Belongs to the G-protein coupled receptor 1 family.
Gene ID 2358
Research Area Signaling
Pathways
Application Notes WB: 1ug/ml. FACS: 1ug/ml
Restrictions For Research Use only
Concentration 1 mg/ml
Buffer PBS, pH 7.2
Storage -20 °C
Background publications Bao, Gerard, Eddy et al.: "Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19." in: Genomics, Vol. 13, Issue 2, pp. 437-40, 1992 (PubMed).

Perez, Holmes, Kelly et al.: "Cloning of a cDNA encoding a receptor related to the formyl peptide receptor of human neutrophils." in: Gene, Vol. 118, Issue 2, pp. 303-4, 1992 (PubMed).

Ye, Cavanagh, Quehenberger et al.: "Isolation of a cDNA that encodes a novel granulocyte N-formyl peptide receptor." in: Biochemical and biophysical research communications, Vol. 184, Issue 2, pp. 582-9, 1992 (PubMed).