Formyl Peptide Receptor 2 (FPR2) antibody

Antigen: Formyl Peptide Receptor 2 (FPR2)

Synonyms: ALXR, HM63, FMLPX, FPR2A, FPRH1, FPRH2, FPRL1, LXA4R, FMLP-R-II, Fpr-rs2, MGC151443, E330010I07Rik, FPR2, Fprl1, ALX, Lxa4r, LXA4-R, Fpr-rs1, FMLP-R-I

Clonality: Polyclonal

Host: Mouse

Reactivity: Human

Application: Western Blotting (WB), Flow Cytometry (FACS)

Catalog no.: ABIN361594

Additional Information

Alternative name: FPRL1

Gene ID: 2358

Immunogen: Recombinant protein of full length Human FPRL1

Format: Affinity-purified

Description: Function: Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to thereceptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium secondmessenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatorysignals such as LTB4 (leukotriene B4) Subcellular location: Cell membrane, Multi-pass membrane protein Tissue specificity: Expressed abundantly in the lung and neutrophils. Also found in the spleen and testis Sequence similarities: Belongs to the G-protein coupled receptor 1 family.

Application Details

Application Notes: WB: 1ug/ml. FACS: 1ug/ml

Concentration: 1 mg/ml

Purification: Protein A purified

Buffer: PBS, pH 7.2

Storage: Store below -20 degrees Celsius

Research Area: Signaling

Restrictions: For Research Use only

Images

FPRL1 transfected 293T cell lysate. Negative control Transfectant

FPRL1 expressing 293 cells 0 0

Publications

Publications: Ye, Cavanagh, Quehenberger et al.: "Isolation of a cDNA that encodes a novel granulocyte N-formyl peptide receptor." in: Biochemical and biophysical research communications, Vol. 184, Issue 2, pp. 582-9, 1992 (PubMed).

Perez, Holmes, Kelly et al.: "Cloning of a cDNA encoding a receptor related to the formyl peptide receptor of human neutrophils." in: Gene, Vol. 118, Issue 2, pp. 303-4, 1992 (PubMed).

Bao, Gerard, Eddy et al.: "Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19." in: Genomics, Vol. 13, Issue 2, pp. 437-40, 1992 (PubMed).