Duffy Blood Group, Chemokine Receptor (DARC) antibody

Antigen: Duffy Blood Group, Chemokine Receptor (DARC)

Synonyms: DARC, FY, Dfy, GPD, GpFy, CCBP1, CD234, WBCQ1

Clonality: Polyclonal

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Catalog no.: ABIN361595

Additional Information

Alternative name: DARC

Gene ID: 2532

Immunogen: Recombinant protein of full length Human DARC

Format: Affinity-purified

Description: Function: Non-specific receptor for many chemokines such as IL-8, GRO, RANTES, MCP-1 and TARC. It is also the receptor for thehuman malaria parasites Plasmodium vivax and Plasmodium knowlesi Subcellular location: Membrane, Multi-pass membrane protein Tissue specificity: Found in adult kidney, adult spleen, bone marrow and fetal liver. In particular, it is expressed along postcapillary venulesthroughout the body, except in the adult liver. Erythroid cells and postcapillary venule endothelium are the principle tissues expressing duffy.Fy(-A-B) individuals do not express duffy in the bone marrow, however they do, in postcapillary venule endothelium Sequence similarities: Belongs to the G-protein coupled receptor Duffy family.

Application Details

Application Notes: WB: 1ug/ml. FACS: 1ug/ml

Concentration: 0.5 mg/ml

Purification: Protein A purified

Buffer: PBS, pH 7.2

Storage: Store below -20 degrees Celsius

Research Area: Signaling

Restrictions: For Research Use only

Images

DARC transfected 293T cell lysate. Negative control Transfectant

DARC expressing 293 cells 0 0

Publications

Tournamille, Colin, Cartron et al.: "Disruption of a GATA motif in the Duffy gene promoter abolishes erythroid gene expression in Duffy-negative individuals." in: Nature genetics, Vol. 10, Issue 2, pp. 224-8, 1995 (PubMed).

Iwamoto, Omi, Kajii et al.: "Genomic organization of the glycoprotein D gene: Duffy blood group Fya/Fyb alloantigen system is associated with a polymorphism at the 44-amino acid residue." in: Blood, Vol. 85, Issue 3, pp. 622-6, 1995 (PubMed).

Chaudhuri, Polyakova, Zbrzezna et al.: "Cloning of glycoprotein D cDNA, which encodes the major subunit of the Duffy blood group system and the receptor for the Plasmodium vivax malaria parasite." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 22, pp. 10793-7, 1993 (PubMed).