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Duffy Blood Group, Chemokine Receptor (DARC) antibody

Details for Product No. ABIN361595, Supplier: Log in to see
Antigen
  • DARC
  • FY
  • ACKR1
  • CCBP1
  • CD234
  • Dfy
  • GPD
  • GpFy
  • WBCQ1
  • AA162249
  • Ackr1
  • ESTM35
Reactivity
Human
83
20
17
Host
Mouse
64
16
6
1
Clonality
Polyclonal
Conjugate
Un-conjugated
3
3
3
2
2
2
1
Application
Flow Cytometry (FACS), Western Blotting (WB)
69
49
34
15
12
5
5
3
3
2
2
2
1
Supplier
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Immunogen Recombinant protein of full length Human DARC
Purification Protein A purified
Alternative Name DARC (DARC Antibody Abstract)
Background Function: Non-specific receptor for many chemokines such as IL-8, GRO, RANTES, MCP-1 and TARC. It is also the receptor for thehuman malaria parasites Plasmodium vivax and Plasmodium knowlesi Subcellular location: Membrane, Multi-pass membrane protein Tissue specificity: Found in adult kidney, adult spleen, bone marrow and fetal liver. In particular, it is expressed along postcapillary venulesthroughout the body, except in the adult liver. Erythroid cells and postcapillary venule endothelium are the principle tissues expressing duffy.Fy(-A-B) individuals do not express duffy in the bone marrow, however they do, in postcapillary venule endothelium Sequence similarities: Belongs to the G-protein coupled receptor Duffy family.
Gene ID 2532
Research Area Signaling
Pathways
Application Notes WB: 1ug/ml. FACS: 1ug/ml
Restrictions For Research Use only
Concentration 0.5 mg/ml
Buffer PBS, pH 7.2
Storage -20 °C
Background publications Chaudhuri, Polyakova, Zbrzezna et al.: "Cloning of glycoprotein D cDNA, which encodes the major subunit of the Duffy blood group system and the receptor for the Plasmodium vivax malaria parasite." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 22, pp. 10793-7, 1993 (PubMed).

Iwamoto, Omi, Kajii et al.: "Genomic organization of the glycoprotein D gene: Duffy blood group Fya/Fyb alloantigen system is associated with a polymorphism at the 44-amino acid residue." in: Blood, Vol. 85, Issue 3, pp. 622-6, 1995 (PubMed).

Tournamille, Colin, Cartron et al.: "Disruption of a GATA motif in the Duffy gene promoter abolishes erythroid gene expression in Duffy-negative individuals." in: Nature genetics, Vol. 10, Issue 2, pp. 224-8, 1995 (PubMed).