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anti-Fy glycoprotein (DARC) antibody

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Image for anti-Fy glycoprotein (DARC) antibody
Antigen: Fy glycoprotein (DARC)
Clonality: Polyclonal
Application: Western Blotting (WB), Flow Cytometry (FACS)
Reactivity: Human
Host: Mouse
3 references available 3 references available
Quantity: 50 ug (0.5 mg/ml)
Price: 589,42 $   (Plus shipping costs and VAT, Invoice in EUR)
Order number: ABIN361595
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Additional Information  » anti-Fy glycoprotein (DARC) antibody

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Antigen Fy glycoprotein (DARC)
Gene ID 2532
Immunogen Recombinant protein of full length Human DARC
Reactivity Human
Host Mouse
Clonality Polyclonal
Format Affinitiy-purified
Description Function: Non-specific receptor for many chemokines such as IL-8, GRO, RANTES, MCP-1 and TARC. It is also the receptor for thehuman malaria parasites Plasmodium vivax and Plasmodium knowlesi Subcellular location: Membrane, Multi-pass membrane protein Tissue specificity: Found in adult kidney, adult spleen, bone marrow and fetal liver. In particular, it is expressed along postcapillary venulesthroughout the body, except in the adult liver. Erythroid cells and postcapillary venule endothelium are the principle tissues expressing duffy.Fy(-A-B) individuals do not express duffy in the bone marrow, however they do, in postcapillary venule endothelium Sequence similarities: Belongs to the G-protein coupled receptor Duffy family.

Application Details  » anti-Fy glycoprotein (DARC) antibody

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Application Western Blotting (WB), Flow Cytometry (FACS)
» Click here to view 7 available protocols!
Application Notes WB: 1ug/ml. FACS: 1ug/ml
Concentration 0.5 mg/ml
Purification Protein A purified
Buffer PBS, pH 7.2
Storage Store below -20 degrees Celsius
Research Area Signaling
Restrictions For Research Use only

Publications  » anti-Fy glycoprotein (DARC) antibody

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Publications Tournamille, Colin, Cartron et al.: "Disruption of a GATA motif in the Duffy gene promoter abolishes erythroid gene expression in Duffy-negative individuals." In: Nature genetics, Vol. 10, Issue 2, pp. 224-8, 1995 (PubMed)

Iwamoto, Omi, Kajii et al.: "Genomic organization of the glycoprotein D gene: Duffy blood group Fya/Fyb alloantigen system is associated with a polymorphism at the 44-amino acid residue." In: Blood, Vol. 85, Issue 3, pp. 622-6, 1995 (PubMed)

Chaudhuri, Polyakova, Zbrzezna et al.: "Cloning of glycoprotein D cDNA, which encodes the major subunit of the Duffy blood group system and the receptor for the Plasmodium vivax malaria parasite." In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 22, pp. 10793-7, 1993 (PubMed)