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UPF3 Regulator of Nonsense Transcripts Homolog A (Yeast) (UPF3A) antibody

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Synonyms 2600001C03Rik, 4930546M19Rik, RENT3A, UPF3, UPF3A, HUPF3A, si:dkey-21o13.6
(29), (4), (4), (2)
(13), (8), (8)
(1), (1), (1), (1), (1), (1)
Immunofluorescence (IF), Western Blotting (WB)
(21), (17), (4), (3), (2), (1), (1)
Pubmed 3 references available
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Quantity 50 μg
Shipping to United States ( )
Availability Will be delivered in 9 to 11 Business Days
Immunogen Recombinant protein of full length Human UPF3A
Purification Protein A purified
Alternative Name UPF3A (UPF3A Antibody Abstract)
Background Function: Part of a multiprotein post-splicing mRNP complex involved in both mRNA nuclear export and mRNA surveillance. Involved innonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Binds spliced mRNA upstream of exon-exon junctions Subcellular location: Nucleus. Cytoplasm. Note: Shuttling between the nucleus and the cytoplasm Tissue specificity: Isoform 1 is strongly expressed in testis, uterus, muscle, fetal brain and spinal cord. Isoform 2 is strongly expressed infetal brain and spinal cord Sequence similarities: Belongs to the RENT3 family.
Gene ID 65110
Application Notes WB: 1ug/ml. IF: 10ug/ml
Restrictions For Research Use only
Concentration 0.5 mg/ml
Buffer PBS, pH 7.2
Storage -20 °C
Background publications Dunham, Matthews, Burton et al.: "The DNA sequence and analysis of human chromosome 13. ..." in: Nature, Vol. 428, Issue 6982, pp. 522-8, 2004 (PubMed).

Lykke-Andersen, Shu, Steitz: "Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon." in: Cell, Vol. 103, Issue 7, pp. 1121-31, 2001 (PubMed).

Serin, Gersappe, Black et al.: "Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4)." in: Molecular and cellular biology, Vol. 21, Issue 1, pp. 209-23, 2001 (PubMed).

Catalog No. ABIN361622
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