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Details for Product No. ABIN361622

UPF3 Regulator of Nonsense Transcripts Homolog A (Yeast) (UPF3A) antibody

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Antigen
Synonyms UPF3, HUPF3A, RENT3A, 2600001C03Rik, 4930546M19Rik, UPF3A, si:dkey-21o13.6
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality Polyclonal
Application
»Alternatives Western Blotting (WB), Immunofluorescence (IF)
Pubmed 3 references available
Catalog no. ABIN361622
Quantity 50 µg
Price
627.13 $   Plus shipping costs $45.00
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Availability Will be delivered in 9 to 11 Business Days
Immunogen Recombinant protein of full length Human UPF3A
Purification Protein A purified
Alternative Name UPF3A
Background Function: Part of a multiprotein post-splicing mRNP complex involved in both mRNA nuclear export and mRNA surveillance. Involved innonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Binds spliced mRNA upstream of exon-exon junctions Subcellular location: Nucleus. Cytoplasm. Note: Shuttling between the nucleus and the cytoplasm Tissue specificity: Isoform 1 is strongly expressed in testis, uterus, muscle, fetal brain and spinal cord. Isoform 2 is strongly expressed infetal brain and spinal cord Sequence similarities: Belongs to the RENT3 family.
Gene ID 65110
Application Notes WB: 1ug/ml. IF: 10ug/ml
Restrictions For Research Use only
Concentration 0.5 mg/ml
Buffer PBS, pH 7.2
Storage -20 °C
Serin, Gersappe, Black et al.: "Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4)." in: Molecular and cellular biology, Vol. 21, Issue 1, pp. 209-23, 2001 (PubMed).

Lykke-Andersen, Shu, Steitz: "Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon." in: Cell, Vol. 103, Issue 7, pp. 1121-31, 2001 (PubMed).

Dunham, Matthews, Burton et al.: "The DNA sequence and analysis of human chromosome 13." in: Nature, Vol. 428, Issue 6982, pp. 522-8, 2004 (PubMed).

Alternatives for antigen "UPF3 Regulator of Nonsense Transcripts Homolog A (Yeast) (UPF3A)", type "Antibodies"
Hosts (5), (5), (2)
Reactivities (11), (2), (2), (1)
Applications (11), (7), (2), (2), (2)
Epitopes (3), (2), (1), (1), (1)
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