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UPF3 Regulator of Nonsense Transcripts Homolog A (Yeast) (UPF3A) antibody

Details for Product No. ABIN361622, Supplier: Login to see
Antigen
  • 2600001C03Rik
  • 4930546M19Rik
  • RENT3A
  • UPF3
  • UPF3A
  • HUPF3A
  • si:dkey-21o13.6
Reactivity
Human
29
4
4
2
Host
Mouse
13
8
8
Clonality
Polyclonal
Conjugate
Un-conjugated
1
1
1
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
21
17
4
3
2
1
1
Supplier
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Immunogen Recombinant protein of full length Human UPF3A
Purification Protein A purified
Alternative Name UPF3A (UPF3A Antibody Abstract)
Background Function: Part of a multiprotein post-splicing mRNP complex involved in both mRNA nuclear export and mRNA surveillance. Involved innonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Binds spliced mRNA upstream of exon-exon junctions Subcellular location: Nucleus. Cytoplasm. Note: Shuttling between the nucleus and the cytoplasm Tissue specificity: Isoform 1 is strongly expressed in testis, uterus, muscle, fetal brain and spinal cord. Isoform 2 is strongly expressed infetal brain and spinal cord Sequence similarities: Belongs to the RENT3 family.
Gene ID 65110
Pathways
Application Notes WB: 1ug/ml. IF: 10ug/ml
Restrictions For Research Use only
Concentration 0.5 mg/ml
Buffer PBS, pH 7.2
Storage -20 °C
Background publications Dunham, Matthews, Burton et al.: "The DNA sequence and analysis of human chromosome 13. ..." in: Nature, Vol. 428, Issue 6982, pp. 522-8, 2004 (PubMed).

Lykke-Andersen, Shu, Steitz: "Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon." in: Cell, Vol. 103, Issue 7, pp. 1121-31, 2001 (PubMed).

Serin, Gersappe, Black et al.: "Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4)." in: Molecular and cellular biology, Vol. 21, Issue 1, pp. 209-23, 2001 (PubMed).