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Essential Meiotic Endonuclease 1 Homolog 1 (S. Pombe) (EME1) antibody
| Antigen | Essential Meiotic Endonuclease 1 Homolog 1 (S. Pombe) (EME1) |
| Synonyms | MMS4L, FLJ31364, gs125, FLJ00151, MGC106543, 6820428D13, EME1, fc30c07, wu:fc30c07, MGC147170 |
| Clonality | Polyclonal |
| Host |
 Alternatives Mouse |
| Reactivity |
Alternatives Human |
| Application |
Alternatives Western Blotting (WB), Immunofluorescence (IF)
|
 |
3 references available |
| Catalog no. | ABIN361624 |
| Quantity | 50 ug (0.5 mg/ml) |
| Price | 619.19 $ Plus shipping costs $35.00 |
| Shipping to |
|
| Availability | Ships within 7 to 10 Business Days |
Additional Information
| Alternative name | EME1 |
| Gene ID | 146956 |
| Immunogen | Recombinant protein of full length Human EME1 |
| Format | Affinity-purified |
| Description | Function: Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structureswith a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be requiredin mitosis for the processing of stalled or collapsed replication forks Subcellular location: Nucleus > nucleolus. Note: Recruited to regions of DNA damage in S-phase cells Sequence similarities: Belongs to the EME1/MMS4 family. |
Application Details
| Application Notes | WB: 1ug/ml. IF: 10ug/ml |
| Concentration | 0.5 mg/ml |
| Purification | Protein A purified |
| Buffer | PBS, pH 7.2 |
| Storage | Store below -20 degrees Celsius |
| Research Area | Enzymes |
| Restrictions | For Research Use only |
Publications
| Publications |
O?sruenuc, Sancar: "Identification and characterization of human MUS81-MMS4 structure-specific endonuclease." in: The Journal of biological chemistry, Vol. 278, Issue 24, pp. 21715-20, 2003 (PubMed).
Ciccia, Constantinou, West: "Identification and characterization of the human mus81-eme1 endonuclease." in: The Journal of biological chemistry, Vol. 278, Issue 27, pp. 25172-8, 2003 (PubMed). Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed). |
Alternatives
Alternatives for antigen "Essential Meiotic Endonuclease 1 Homolog 1 (S. Pombe) (EME1)", type "Antibodies"
| Hosts | Rabbit (8), Mouse (6) |
| Reactivities | Human (11) |
| Applications | Western Blotting (WB) (14), ELISA (4), Enzyme Immunoassay (EIA) (3), ELISA (Detection) (2), Immunofluorescence (IF) (2) |
| Epitopes | Center (1), N-Term (1) |
