Phosphothreonine (pThr) antibody (HRP)

Details for Product No. ABIN361681
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Antigen
Epitope
pThr
(11), (1)
Reactivity
All Species
(48), (4), (3), (1)
Host
Rabbit
(39), (17)
Clonality
Polyclonal
Conjugate
HRP
(6), (6)
Application
Western Blotting (WB), ELISA
(50), (34), (26), (16), (8), (2), (2), (2), (1), (1)
Pubmed 5 references available
Quantity 400 μL
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Catalog No. ABIN361681
457.60 $
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Immunogen Phosphothreonine conjugated to KLH
Isotype IgG
Specificity Recognizes proteins phosphorylated on threonine residues. Does not cross-react with phosphotyrosine.
Cross-Reactivity (Details) Does not cross-react with phosphotyrosine.
Background Protein phosphorylation is an important posttranslational modification that serves many key functions to regulate a protein’s activity, localization, and protein-protein interactions. Phosphorylation is catalyzed by various specific protein kinases, which involves removing a phosphate group from ATP and covalently attaching it to to a recipient protein that acts as a substrate. Most kinases act on both serine and threonine, others act on tyrosine, and a number (dual specificity kinases) act on all three. Because phosphorylation can occur at multiple sites on any given protein, it can therefore change the function or localization of that protein at any time. Changing the function of these proteins has been linked to a number of diseases, including cancer, diabetes, heart disease, inflammation and neurological disorders.
Research Area Signaling, Metabolism, Amino Acids, Protein Modifications, Cell Signaling, Phosphorylation
Application Notes Recommended Dilution: 1:500 (WB)
Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ mL
Buffer PBS, 50 % glycerol, 0.09 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Background publications Ostrovsky, Maloy: "Protein phosphorylation on serine, threonine, and tyrosine residues modulates membrane-protein interactions and transcriptional regulation in Salmonella typhimurium." in: Genes & development, Vol. 9, Issue 16, pp. 2034-41, 1995 (PubMed).

Pawson, Saxton: "Signaling networks--do all roads lead to the same genes?" in: Cell, Vol. 97, Issue 6, pp. 675-8, 1999 (PubMed).

Blume-Jensen, Hunter: "Oncogenic kinase signalling." in: Nature, Vol. 411, Issue 6835, pp. 355-65, 2001 (PubMed).

Downward: "The ins and outs of signalling." in: Nature, Vol. 411, Issue 6839, pp. 759-62, 2001 (PubMed).

Goto, Kiyono, Tomono et al.: "Complex formation of Plk1 and INCENP required for metaphase-anaphase transition." in: Nature cell biology, Vol. 8, Issue 2, pp. 180-7, 2006 (PubMed).

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