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Phosphoserine (pSer) antibody (HRP)
Alternatives Western Blotting (WB), ELISA
|5 references available|
|Price||429.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 3 to 4 Business Days|
|Immunogen||Phosphoserine conjugated to KLH|
|Description||Protein phosphorylation is an important posttranslational modification that serves many key functions to regulate a protein’s activity, localization, and protein-protein interactions. Phosphorylation is catalyzed by various specific protein kinases, which involves removing a phosphate group from ATP and covalently attaching it to to a recipient protein that acts as a substrate. Most kinases act on both serine and threonine, others act on tyrosine, and a number (dual specificity kinases) act on all three. Because phosphorylation can occur at multiple sites on any given protein, it can therefore change the function or localization of that protein at any time. Changing the function of these proteins has been linked to a number of diseases, including cancer, diabetes, heart disease, inflammation and neurological disorders.|
|Specificity||Recognizes proteins phosphorylated on serine residues. Does not cross-react with phosphotyrosine.|
|Application Notes||1:500 (WB)|
|Buffer||HRP Stabilizing buffer|
|Storage||Store at -20° C. Shipping Temperature: Blue Ice or 4° C|
|Storage Shipping Temp Max||Blue Ice or 4 °C|
|Research Area||Cell Signaling, Phosphorylation, Neurology, Metabolism, Amino Acids, Protein Modifications|
|Restrictions||For Research Use only|
Ostrovsky, Maloy: "Protein phosphorylation on serine, threonine, and tyrosine residues modulates membrane-protein interactions and transcriptional regulation in Salmonella typhimurium." in: Genes & development, Vol. 9, Issue 16, pp. 2034-41, 1995 (PubMed).
Pawson, Saxton: "Signaling networks--do all roads lead to the same genes?" in: Cell, Vol. 97, Issue 6, pp. 675-8, 1999 (PubMed).
Blume-Jensen, Hunter: "Oncogenic kinase signalling." in: Nature, Vol. 411, Issue 6835, pp. 355-65, 2001 (PubMed).
Downward: "The ins and outs of signalling." in: Nature, Vol. 411, Issue 6839, pp. 759-62, 2001 (PubMed).
Goto, Kiyono, Tomono et al.: "Complex formation of Plk1 and INCENP required for metaphase-anaphase transition." in: Nature cell biology, Vol. 8, Issue 2, pp. 180-7, 2006 (PubMed).
|Hosts||Rabbit (35), Mouse (23)|
|Reactivities||Dog (Canine) (7), All Species (1), Human (1), Various Species (1)|
|Applications||Western Blotting (WB) (56), ELISA (53), Immunoprecipitation (IP) (35), Immunohistochemistry (IHC) (6), Immunofluorescence (IF) (2), Enzyme Immunoassay (EIA) (1), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (1)|
|Conjugates||HRP (9), Biotin (8)|