Phosphoserine (pSer) antibody (HRP)

Details for Product No. ABIN361695
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Epitope
pSer
(18), (1)
Reactivity
All Species
(71), (4), (4), (1), (1)
Host
Rabbit
(41), (35)
Clonality
Polyclonal
Conjugate
HRP
(7), (7), (1), (1)
Application
Western Blotting (WB), ELISA
(70), (44), (41), (16), (8), (4), (4), (3), (3), (2), (2), (1)
Pubmed 5 references available
Quantity 400 μL
Options
Shipping to United States (Change)
Availability Will be delivered in 3 to 4 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN361695
457.60 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Phosphoserine conjugated to KLH
Isotype IgG
Specificity Recognizes proteins phosphorylated on serine residues. Does not cross-react with phosphotyrosine.
Cross-Reactivity (Details) Does not cross-react with phosphotyrosine.
Background Protein phosphorylation is an important posttranslational modification that serves many key functions to regulate a protein’s activity, localization, and protein-protein interactions. Phosphorylation is catalyzed by various specific protein kinases, which involves removing a phosphate group from ATP and covalently attaching it to to a recipient protein that acts as a substrate. Most kinases act on both serine and threonine, others act on tyrosine, and a number (dual specificity kinases) act on all three. Because phosphorylation can occur at multiple sites on any given protein, it can therefore change the function or localization of that protein at any time. Changing the function of these proteins has been linked to a number of diseases, including cancer, diabetes, heart disease, inflammation and neurological disorders.
Research Area Neurology, Metabolism, Amino Acids, Protein Modifications, Cell Signaling, Phosphorylation
Application Notes Recommended Dilution: 1:500 (WB)
Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ mL
Buffer HRP Stabilizing buffer: The HRP stabilizing buffer contains PBS, 0.1 % BSA, 0.01 % proclin 150, and 50 % glycerol
Preservative ProClin
Storage -20 °C
Background publications Ostrovsky, Maloy: "Protein phosphorylation on serine, threonine, and tyrosine residues modulates membrane-protein interactions and transcriptional regulation in Salmonella typhimurium." in: Genes & development, Vol. 9, Issue 16, pp. 2034-41, 1995 (PubMed).

Pawson, Saxton: "Signaling networks--do all roads lead to the same genes?" in: Cell, Vol. 97, Issue 6, pp. 675-8, 1999 (PubMed).

Blume-Jensen, Hunter: "Oncogenic kinase signalling." in: Nature, Vol. 411, Issue 6835, pp. 355-65, 2001 (PubMed).

Downward: "The ins and outs of signalling." in: Nature, Vol. 411, Issue 6839, pp. 759-62, 2001 (PubMed).

Goto, Kiyono, Tomono et al.: "Complex formation of Plk1 and INCENP required for metaphase-anaphase transition." in: Nature cell biology, Vol. 8, Issue 2, pp. 180-7, 2006 (PubMed).

Validation Images
Did you look for something else?
back to top