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RPS6KA1 antibody (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1) (C-Term)

Details for Product anti-RPS6KA1 Antibody No. ABIN361702, Supplier: Log in to see
Antigen
  • Rsk1
  • p90rsk
  • rsk
  • HU-1
  • MAPKAPK1A
  • RSK
  • RSK1
  • RPS6KA
  • hu-1
  • mapkapk1a
  • rsk1
  • CLS
  • HU-3
  • ISPK-1
  • MAPKAPK1B
  • MRX19
  • RSK2
  • S6K-alpha3
  • p90-RSK2
  • pp90RSK2
Alternatives
anti-Cow (Bovine) RPS6KA1 antibody for Immunoprecipitation
Epitope
C-Term
63
39
31
24
22
18
15
12
10
9
9
8
7
6
6
4
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Cow (Bovine), Human, Mouse (Murine), Rat (Rattus)
307
141
111
27
11
6
6
2
2
1
Host
Rabbit
306
38
Clonality
Polyclonal
Conjugate
This RPS6KA1 antibody is un-conjugated
20
19
17
12
12
12
5
5
5
5
5
5
5
5
4
1
1
1
1
1
1
1
1
1
1
1
Application
Immunoprecipitation (IP), ELISA, Western Blotting (WB)
239
153
92
54
48
38
31
20
7
7
1
1
1
Supplier
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Immunogen Human p90 RSK1 C-terminal peptide, conjugated to KLH
Specificity Detects ~90 kDa.
Purification Rabbit immunoglobulin
Alternative Name RSK1 (RPS6KA1 Antibody Abstract)
Background The p90 ribosomal S6 kinase (Rsk) family comprises four mammalian serine/threonine kinases (Rsk1-4). In the past, S6K1 and S6K2 were thought to be the predominant operating S6 kinases, however RSK 1 and 2 have been shown to phosphorylate S6 in response to the ERK pathway, or otherwise known as the extra cellular signal-regulated kinases pathway. RSK 1 in particular is very multifunctional as it participates in nuclear signaling, regulates nuclear factors, regulates several transcription factors like c-Fos, and interacts with the transcriptional coactivator CREB-binding protein. As a result, RSK1 seems to have an important role in cellular growth control and proliferation. (1-5).
Gene ID 6195
NCBI Accession NP_002944
UniProt Q15418
Research Area Cell Signaling, Phosphorylation
Pathways MAPK Signaling, Neurotrophin Signaling Pathway
Application Notes Recommended Dilution: WB (1:1000)
Optimal dilutions for assays should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer TBS, 50 % glycerol, 0.09 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
Western Blotting (WB) image for anti-RPS6KA1 antibody (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1) (C-Term) (ABIN361702) P90 RSK1, IP and Western Blotting, mouse brain extract (A) and (B) neg IP control.
Background publications Frödin, Gammeltoft: "Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction." in: Molecular and cellular endocrinology, Vol. 151, Issue 1-2, pp. 65-77, 1999 (PubMed).

Merienne, Jacquot, Trivier et al.: "Rapid immunoblot and kinase assay tests for a syndromal form of X linked mental retardation: Coffin-Lowry syndrome." in: Journal of medical genetics, Vol. 35, Issue 11, pp. 890-4, 1999 (PubMed).

De Cesare, Jacquot, Hanauer et al.: "Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c-fos gene." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 21, pp. 12202-7, 1998 (PubMed).

Joel, Smith, Sturgill et al.: "pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167." in: Molecular and cellular biology, Vol. 18, Issue 4, pp. 1978-84, 1998 (PubMed).