Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 (RPS6KA1) (C-Term) antibody

Details for Product No. ABIN361702
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Antigen
Synonyms Rsk1, p90rsk, rsk, HU-1, MAPKAPK1A, RSK, RSK1, RPS6KA, hu-1, mapkapk1a, rsk1, CLS, HU-3, ISPK-1, MAPKAPK1B, MRX19, RSK2, S6K-alpha3, p90-RSK2, pp90RSK2
Epitope
C-Term
(32), (21), (20), (20), (17), (9), (9), (7), (7), (6), (6), (6), (5), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus), Cow (Bovine)
(214), (88), (74), (43), (42), (36), (27), (5), (2)
Host
Rabbit
(203), (26)
Clonality
Polyclonal
Conjugate
Un-conjugated
(12), (12), (10), (6), (6), (6), (4), (4), (4), (4), (4), (4), (4), (4)
Application
Western Blotting (WB), Immunoprecipitation (IP), ELISA
(170), (94), (50), (42), (40), (25), (17), (15), (12), (2)
Pubmed 4 references available
Quantity 400 µL
Options
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Catalog No. ABIN361702
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Immunogen Human p90 RSK1 C-terminal peptide conjugated to KLH
Isotype IgG
Specificity Detects a approx. 90 kDa protein corresponding to the molecular mass of p90 RSK1 on SDS PAGE immunoblots.
Alternative Name p90 RSK1
Background Synonyms:
RSK1 p90, HU1, MAPKAP, p90rsk, p90S6K, RSK1, RSK 1 p90
The p90 ribosomal S6 kinase (Rsk) family comprises four mammalian serine/threonine kinases (Rsk1–4). In the past, S6K1 and S6K2 were thought to be the predominant operating S6 kinases, however RSK 1 and 2 have been shown to phosphorylate S6 in response to the ERK pathway, or otherwise known as the extra cellular signal-regulated kinases pathway. RSK 1 in particular is very multifunctional as it participates in nuclear signaling, regulates nuclear factors, regulates several transcription factors like c-Fos, and interacts with the transcriptional coactivator CREB-binding protein. As a result, RSK1 seems to have an important role in cellular growth control and proliferation..
Gene ID 6195
NCBI Accession NP_002944
UniProt Q15418
Research Area Cell Signaling, Phosphorylation
Application Notes Recommended Dilution: 1 µg/mL (WB)
Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ mL
Buffer TBS, 50 % glycerol, 0.09 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 (RPS6KA1) (C-Term) antibody P90 RSK1, IP and Western Blotting, mouse brain extract (A) and (B) neg IP control.
Background publications Joel, Smith, Sturgill et al.: "pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167." in: Molecular and cellular biology, Vol. 18, Issue 4, pp. 1978-84, 1998 (PubMed).

De Cesare, Jacquot, Hanauer et al.: "Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c-fos gene." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 21, pp. 12202-7, 1998 (PubMed).

Merienne, Jacquot, Trivier et al.: "Rapid immunoblot and kinase assay tests for a syndromal form of X linked mental retardation: Coffin-Lowry syndrome." in: Journal of medical genetics, Vol. 35, Issue 11, pp. 890-4, 1999 (PubMed).

Frödin, Gammeltoft: "Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction." in: Molecular and cellular endocrinology, Vol. 151, Issue 1-2, pp. 65-77, 1999 (PubMed).

Validation Images
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