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Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 (RPS6KA1) antibody

Antigen

Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 (RPS6KA1)

Synonyms RSK, HU-1, RSK1, MAPKAPK1A
Clonality Polyclonal
Host
Alternatives

Rabbit

Reactivity
Alternatives

Human, Mouse (Murine), Guinea Pig, Cow (Bovine)

Application
Alternatives Western Blotting (WB), Immunoprecipitation (IP), ELISA
4 references available
Catalog no. ABIN361702
Quantity 400myl  (250µg/mL)  (Variants)
Price 215.00 $   Plus shipping costs $35.00
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Additional Information

Characteristics Detects a ~90kDa protein corresponding to the molecular mass of p90 RSK1 on SDS PAGE immunoblots.
Alternative name p90 RSK1
Gene ID NP_002944.2, 6195
Immunogen Human p90 RSK1 C-terminal peptide, conjugated to KLH
Format Liquid
Description The p90 ribosomal S6 kinase (Rsk) family comprises four mammalian serine/threonine kinases (Rsk1–4). In the past, S6K1 and S6K2 were thought to be the predominant operating S6 kinases, however RSK 1 and 2 have been shown to phosphorylate S6 in response to the ERK pathway, or otherwise known as the extra cellular signal-regulated kinases pathway. RSK 1 in particular is very multifunctional as it participates in nuclear signaling, regulates nuclear factors, regulates several transcription factors like c-Fos, and interacts with the transcriptional coactivator CREB-binding protein. As a result, RSK1 seems to have an important role in cellular growth control and proliferation. (1-5).
Synonyms: RSK1 p90, HU1, MAPKAP, p90rsk, p90S6K, RSK1, RSK 1 p90
Specificity Detects an ~90kDa protein, corresponding to the molecular mass of p90 RSK1 on SDS-PAGE immunoblots. Species cross-reactivity: Human, Mouse, Rat, Bovine.

Application Details

Application Notes 1ug/ml was needed for western blot analysis.
Concentration 250µg/mL
Buffer TBS, 50% glycerol, 0.09% sodium azide
Storage -20 °C
Storage Shipping Temp Max Blue Ice or 4 °C
Research Area Cell Signaling
Restrictions For Research Use only

Publications

Publications Joel, Smith, Sturgill et al.: "pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167." in: Molecular and cellular biology, Vol. 18, Issue 4, pp. 1978-84, 1998 (PubMed).

De Cesare, Jacquot, Hanauer et al.: "Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c-fos gene." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 21, pp. 12202-7, 1998 (PubMed).

Merienne, Jacquot, Trivier et al.: "Rapid immunoblot and kinase assay tests for a syndromal form of X linked mental retardation: Coffin-Lowry syndrome." in: Journal of medical genetics, Vol. 35, Issue 11, pp. 890-4, 1999 (PubMed).

Froedin, Gammeltoft: "Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction." in: Molecular and cellular endocrinology, Vol. 151, Issue 1-2, pp. 65-77, 1999 (PubMed).

Alternatives

Alternatives for antigen "Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 (RPS6KA1)", type "Antibodies"
Hosts Rabbit (67), Mouse (5)
Reactivities Human (71), Mouse (Murine) (37), Rat (Rattus) (35), Cow (Bovine) (7), Dog (Canine) (5), Chicken (3), Horse (Equine) (3), Pig (Porcine) (2), Rabbit (1)
Applications Western Blotting (WB) (55), Immunofluorescence (IF) (22), Enzyme Immunoassay (EIA) (18), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (14), ELISA (10), Immunohistochemistry (IHC) (9), Flow Cytometry (FACS) (6), Immunoprecipitation (IP) (5), Dot Blot (Dot) (4), Immunocytochemistry (ICC) (1), Immunohistochemistry (Frozen Sections) (IHC (fro)) (1)
Conjugates Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), PE,Cy5.5 (1)
Epitopes pThr348 (8), N-Term (4), pTyr515 (4), pSer352 (3), S363 (2), T359 (2), pSer363 (2), pSer732 (2), pThr359 (2), C-Term (1), S732 (1), pS732 (1), pSer364 (1), pSer380 (1), pThr573 (1)