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Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 (RPS6KA1) antibody

Antigen

Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 (RPS6KA1)
Synonyms RSK, HU-1, RSK1, MAPKAPK1A
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human, Mouse (Murine), Rat (Rattus), Cow (Bovine)
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB), Immunoprecipitation (IP), ELISA
4 references available
Catalog no. ABIN361702
Quantity 400µl  (250µg/mL)  (Variants)
Price 236.50 $   Plus shipping costs $45.00
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anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 (RPS6KA1) antibody

Additional Information
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Alternative name p90 RSK1
Gene ID 6195
UniProt Q15418
Immunogen Human p90 RSK1 C-terminal peptide, conjugated to KLH
Description The p90 ribosomal S6 kinase (Rsk) family comprises four mammalian serine/threonine kinases (Rsk1–4). In the past, S6K1 and S6K2 were thought to be the predominant operating S6 kinases, however RSK 1 and 2 have been shown to phosphorylate S6 in response to the ERK pathway, or otherwise known as the extra cellular signal-regulated kinases pathway. RSK 1 in particular is very multifunctional as it participates in nuclear signaling, regulates nuclear factors, regulates several transcription factors like c-Fos, and interacts with the transcriptional coactivator CREB-binding protein. As a result, RSK1 seems to have an important role in cellular growth control and proliferation..
Synonyms: RSK1 p90, HU1, MAPKAP, p90rsk, p90S6K, RSK1, RSK 1 p90
Characteristics Accession Number: NP_002944.2
Specificity Detects a ~90kDa protein corresponding to the molecular mass of p90 RSK1 on SDS PAGE immunoblots.

Application Details
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Application Notes 1µg/mL (WB)
Concentration 250µg/mL
Purification Rabbit immunoglobulin
Buffer TBS, 50% glycerol
Preservative 0.09% sodium azide
Storage Store at -20° C. Shipping Temperature: Blue Ice or 4° C
Storage Shipping Temp Max Blue Ice or 4 °C
Research Area Cell Signaling, Phosphorylation
Restrictions For Research Use only

Publications
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Joel, Smith, Sturgill et al.: "pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167." in: Molecular and cellular biology, Vol. 18, Issue 4, pp. 1978-84, 1998 (PubMed).

De Cesare, Jacquot, Hanauer et al.: "Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c-fos gene." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 21, pp. 12202-7, 1998 (PubMed).

Merienne, Jacquot, Trivier et al.: "Rapid immunoblot and kinase assay tests for a syndromal form of X linked mental retardation: Coffin-Lowry syndrome." in: Journal of medical genetics, Vol. 35, Issue 11, pp. 890-4, 1999 (PubMed).

Froedin, Gammeltoft: "Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction." in: Molecular and cellular endocrinology, Vol. 151, Issue 1-2, pp. 65-77, 1999 (PubMed).

Alternatives
Application Details Publications Images Variants back to top

Alternatives for antigen "Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 (RPS6KA1)", type "Antibodies"
Hosts Rabbit (151), Mouse (11)
Reactivities Human (152), Rat (Rattus) (80), Mouse (Murine) (79), Cow (Bovine) (38), Dog (Canine) (34), Horse (Equine) (34), Pig (Porcine) (29), Chicken (5)
Applications Western Blotting (WB) (98), ELISA (49), Immunofluorescence (IF) (49), Immunohistochemistry (IHC) (30), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (28), Flow Cytometry (FACS) (17), Immunoprecipitation (IP) (12), Immunocytochemistry (ICC) (4), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Dot Blot (Dot) (2), Fluorescence Microscopy (FM) (1), Immunoelectron Microscopy (IEM) (1), Immunohistochemistry (Fixed) (IHC (fx)) (1)
Conjugates Alexa Fluor 350 (8), Alexa Fluor 488 (8), Alexa Fluor 555 (8), Alexa Fluor 647 (8), PE,Cy5.5 (8), Biotin (2), HRP (2), Alexa Flour 488 (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1)
Epitopes pThr348 (14), pSer352 (10), C-Term (9), N-Term (9), pSer363 (8), pSer380 (8), pThr359 (8), pThr573 (7), pSer363,pThr359 (5), Internal Region (3), Ser352 (3), Thr348 (3), pSer732 (3), Ser363 (2), Ser732 (2), Thr359 (2), pThr359, pSer363 (2), AA 2-110 (1), Asp659 (1), C-Term,pSer732 (1), Glu718 (1), pSer176 (1), pSer221, pSer227 (1), pSer363, pSer369 (1), pSer369 (1), pSer380, pSer386 (1), pSer732,C-Term (1), pThr368, pSer372 (1), pThr368,pSer372 (1)