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Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 (RPS6KA1) antibody
|Synonyms||RSK, HU-1, RSK1, MAPKAPK1A|
Human, Mouse (Murine), Rat (Rattus), Cow (Bovine)
Alternatives Western Blotting (WB), Immunoprecipitation (IP), ELISA
|4 references available|
|Quantity||400µl (250µg/mL) (Variants)|
|Price||236.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 3 to 4 Business Days|
|Alternative name||p90 RSK1|
|Immunogen||Human p90 RSK1 C-terminal peptide, conjugated to KLH|
The p90 ribosomal S6 kinase (Rsk) family comprises four mammalian serine/threonine kinases (Rsk1–4). In the past, S6K1 and S6K2 were thought to be the predominant operating S6 kinases, however RSK 1 and 2 have been shown to phosphorylate S6 in response to the ERK pathway, or otherwise known as the extra cellular signal-regulated kinases pathway. RSK 1 in particular is very multifunctional as it participates in nuclear signaling, regulates nuclear factors, regulates several transcription factors like c-Fos, and interacts with the transcriptional coactivator CREB-binding protein. As a result, RSK1 seems to have an important role in cellular growth control and proliferation..
Synonyms: RSK1 p90, HU1, MAPKAP, p90rsk, p90S6K, RSK1, RSK 1 p90
|Characteristics||Accession Number: NP_002944.2|
|Specificity||Detects a ~90kDa protein corresponding to the molecular mass of p90 RSK1 on SDS PAGE immunoblots.|
|Application Notes||1µg/mL (WB)|
|Buffer||TBS, 50% glycerol|
|Preservative||0.09% sodium azide|
|Storage||Store at -20° C. Shipping Temperature: Blue Ice or 4° C|
|Storage Shipping Temp Max||Blue Ice or 4 °C|
|Research Area||Cell Signaling, Phosphorylation|
|Restrictions||For Research Use only|
|P90 RSK1, IP and Western Blotting, mouse brain extract (A) and (B) neg IP control.|
Joel, Smith, Sturgill et al.: "pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167." in: Molecular and cellular biology, Vol. 18, Issue 4, pp. 1978-84, 1998 (PubMed).
De Cesare, Jacquot, Hanauer et al.: "Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c-fos gene." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 21, pp. 12202-7, 1998 (PubMed).
Merienne, Jacquot, Trivier et al.: "Rapid immunoblot and kinase assay tests for a syndromal form of X linked mental retardation: Coffin-Lowry syndrome." in: Journal of medical genetics, Vol. 35, Issue 11, pp. 890-4, 1999 (PubMed).
Froedin, Gammeltoft: "Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction." in: Molecular and cellular endocrinology, Vol. 151, Issue 1-2, pp. 65-77, 1999 (PubMed).