Discs, Large Homolog 4 (Drosophila) (DLG4) antibody

Antigen: Discs, Large Homolog 4 (Drosophila) (DLG4)

Synonyms: PSD95, SAP90, SAP-90, FLJ97752, FLJ98574, DAP2, SAPAP2, Dlgh4, PSD-95, SAP90A, Sap90, 11, anon-EST:Posey93, anon-WO03040301.258, anon-WO03040301.260, anon-WO03040301.268, CG1725, CG1730, CPD, d. lg.-1, Discs-large, dlg, Dlg, DLG, dlg-1, dlg-A, Dlg-A, DLG-A, Dlg1, dlgA, DlgA, DmelCG1725, Drodlg, l(1)10Bf, l(1)bwn, l(1)d.lg-1, l(1)d.lg.-1, l(1)discs large, l(1)dlg, l(1)dlg-1, l(1)dlg1, l(1)G0276, l(1)G0342, l(1)G0456, l(1)G19, l(1)l.pr.-2, l(1)L11, l(1)lpr-2, misb, SAP97, Sapap2, 6430596N04Rik, dlgh4, psd95, sap90, sap-90, LLGL1

Clonality: Monoclonal (7E3)

Host: Mouse

Reactivity: Mouse (Murine), Rat (Rattus), Cow (Bovine)

Conjugate: Un-conjugated

Application: Western Blotting (WB)

Catalog no.: ABIN361721

Additional Information

Alternative name: PSD95

Gene ID: 29495

UniProt: P31016

Immunogen: Recombinant rat PSD-95

Isotype: IgG2a

Clone: 7E3

Description: Synonyms: DLG4, SAP90

Characteristics: Accession Number: NP_031890.1

Specificity: Detects a ~100kDa protein corresponding to the molecular mass of PSD-95 on SDS PAGE immunoblots. Additional cross-reactive bands are detected at ~80kDa and ~50kDa in rat and mouse samples.

Sensitivity: 1µg/ml was sufficient for detection of PSD-95 on 20µg rat brain tissue extract by ECL immunoblot analysis using Goat Anti-Mouse igG:HRP as the secondary.

Synonyms: PSD95, SAP90, SAP-90, FLJ97752, FLJ98574, DAP2, SAPAP2, Dlgh4, PSD-95, SAP90A, Sap90, 11, anon-EST:Posey93, anon-WO03040301.258, anon-WO03040301.260, anon-WO03040301.268, CG1725, CG1730, CPD, d. lg.-1, Discs-large, dlg, Dlg, DLG, dlg-1, dlg-A, Dlg-A, DLG-A, Dlg1, dlgA, DlgA, DmelCG1725, Drodlg, l(1)10Bf, l(1)bwn, l(1)d.lg-1, l(1)d.lg.-1, l(1)discs large, l(1)dlg, l(1)dlg-1, l(1)dlg1, l(1)G0276, l(1)G0342, l(1)G0456, l(1)G19, l(1)l.pr.-2, l(1)L11, l(1)lpr-2, misb, SAP97, Sapap2, 6430596N04Rik, dlgh4, psd95, sap90, sap-90, LLGL1

Application Details

Application Notes: 1µg/ml was sufficient for detection of PSD-95 on 20µg rat brain tissue extract.

Concentration: 1mg/mL

Purification: Protein G Purified

Buffer: PBS pH7.4, 50% glycerol

Storage: Store at -20° C. Shipping Conditions: Blue Ice or 4° C

Storage Shipping Temp Max: Blue Ice or 4 °C

Research Area: Neurology, Organelles

Restrictions: For Research Use only

Images

western rat membrane 1 in 1000 PSD 95.

Publications

Kennedy: "The postsynaptic density at glutamatergic synapses." in: Trends in neurosciences, Vol. 20, Issue 6, pp. 264-8, 1997 (PubMed).

Irie, Hata, Takeuchi et al.: "Binding of neuroligins to PSD-95." in: Science (New York, N.Y.), Vol. 277, Issue 5331, pp. 1511-5, 1997 (PubMed).

Chetkovich, Bunn, Kuo et al.: "Postsynaptic targeting of alternative postsynaptic density-95 isoforms by distinct mechanisms." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 22, Issue 15, pp. 6415-25, 2002 (PubMed).

Yao, Gainetdinov, Arbuckle et al.: "Identification of PSD-95 as a regulator of dopamine-mediated synaptic and behavioral plasticity." in: Neuron, Vol. 41, Issue 4, pp. 625-38, 2004 (PubMed).

Cao, Viholainen, Dart et al.: "The PSD95-nNOS interface: a target for inhibition of excitotoxic p38 stress-activated protein kinase activation and cell death." in: The Journal of cell biology, Vol. 168, Issue 1, pp. 117-26, 2005 (PubMed).

Cline: "Synaptogenesis: a balancing act between excitation and inhibition." in: Current biology : CB, Vol. 15, Issue 6, pp. R203-5, 2005 (PubMed).

Cai, Li, Rivera et al.: "Interaction between SAP97 and PSD-95, two Maguk proteins involved in synaptic trafficking of AMPA receptors." in: The Journal of biological chemistry, Vol. 281, Issue 7, pp. 4267-73, 2006 (PubMed).