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Details for Product No. ABIN361723

V-Akt Murine Thymoma Viral Oncogene Homolog 2 (AKT2) antibody

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Antigen
Synonyms HIHGHH, PKBB, PKBBETA, PRKBB, RAC-BETA, cb945, 2410016A19Rik, AW554154, PKB, PKBbeta, akt2-a, pkbb, pkbbeta, pkbss, prkbb, rac-beta, v-akt2, AKT2
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus), Cow (Bovine), Chicken, Dog (Canine), Guinea Pig, Hamster, Monkey, Pig (Porcine), Rabbit, Sheep (Ovine), Xenopus laevis
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), ELISA
Pubmed 3 references available
Catalog no. ABIN361723
Quantity 400 µL
Price
432.70 $   Plus shipping costs $45.00
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Availability Will be delivered in 3 to 4 Business Days
Immunogen A five residue synthetic peptide based on the human Akt2 coupled to KLH
Isotype IgG
Specificity Detects a 65 kDa protein, corresponding to the molecular mass of Akt2 PKBβ on SDS PAGE immunoblots.
Cross-Reactivity (Details) Does not react with PKBα (Akt1) or PKBγ (Akt3).
Alternative Name Akt2 (PKB beta)
Background Synonyms:
AKT2, PKB, PKB beta, PRKBB, protein kinase Akt2, RAC BETA
Protein kinase B or Akt (PKB/Akt) is a serine/threonine kinase, which in mammals comprises three highly homologous members known as PKB alpha (Akt1), PKB beta (Akt2) and PKB gamma (Akt3). PKB/Akt is a growth-factor-regulated protein kinase which contains a Pleckstrin Homology (PH) domain which might be important for dimerization of the kinase. Binding of phosphoinositide 3-OH kinase products to the pleckstrin homology domain results in translocation of PKB/Akt to the plasma membrane where it is activated by phosphorylation by upstream kinases including thephosphoinoside-dependent kinase 1 (PDK1) and PDK2. Myelin basic protein and histone H2B are in vitro substrates for PKB, while glycogen synthase kinase-3 has been implicated as a physiological target. Key roles for this enzyme can be found in cellular processes such as glucose metabolism, cell proliferation, apoptosis, transcription and cell migration.
Gene ID 208
NCBI Accession NP_001617.1
UniProt P31751
Research Area Cell Signaling, Phosphorylation
Application Notes Recommended Dilution: 1:3000 dilution was sufficient for detection of PKBβ in 20 µg of HeLa cell lysate by ECL immunoblot analysis.
Restrictions For Research Use only
Concentration 0.25 mg/mL
Buffer TBS, 50 % glycerol, 0.09 % sodium azide
Preservative Sodium azide
Storage -20 °C
Background publications Downward: "Mechanisms and consequences of activation of protein kinase B/Akt." in: Current opinion in cell biology, Vol. 10, Issue 2, pp. 262-7, 1998 (PubMed).

Brazil, Hemmings: "Ten years of protein kinase B signalling: a hard Akt to follow." in: Trends in biochemical sciences, Vol. 26, Issue 11, pp. 657-64, 2001 (PubMed).

Nicholson, Anderson: "The protein kinase B/Akt signalling pathway in human malignancy." in: Cellular signalling, Vol. 14, Issue 5, pp. 381-95, 2002 (PubMed).

Alternatives for antigen "V-Akt Murine Thymoma Viral Oncogene Homolog 2 (AKT2)", type "Antibodies"
Hosts (147), (47), (7), (3), (2)
Reactivities (205), (98), (88), (21), (20), (19), (19), (10), (2), (1), (1), (1), (1), (1), (1)
Applications (168), (84), (57), (48), (41), (40), (20), (15), (6), (4), (2), (1), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1)
Epitopes (43), (13), (10), (9), (5), (5), (4), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
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