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V-Akt Murine Thymoma Viral Oncogene Homolog 2 (AKT2) antibody
| Antigen | V-Akt Murine Thymoma Viral Oncogene Homolog 2 (AKT2) |
| Synonyms | PKBB, PRKBB, PKBBETA, RAC-BETA, AKT2, cb945, prkbb, v-akt2, pkbbeta, rac-beta |
| Clonality | Polyclonal |
| Host |
Alternatives Rabbit |
| Reactivity |
Alternatives Human, Mouse (Murine), Guinea Pig, Cow (Bovine), Chicken, Dog (Canine), Hamster, Monkey, Pig (Porcine), Rabbit, Sheep (Ovine), Xenopus laevis |
| Application |
Alternatives Western Blotting (WB), ELISA
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3 references available |
| Catalog no. | ABIN361723 |
| Quantity | 400myl (0.25mg/mL) (Variants) |
| Price | 290.00 $ Plus shipping costs $35.00 |
| Shipping to |
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| Availability | Ships within 7 to 10 Business Days |
Additional Information
| Characteristics | Detects a 65kDa protein, corresponding to the molecular mass of Akt2 PKBbeta on SDS PAGE immunoblots. Does not react with PKBalpha (Akt1) or PKBgamma (Akt3). |
| Alternative name | Akt2 (PKBbeta) |
| Gene ID | NP_001617.1, 208 |
| Immunogen | A five residue synthetic peptide based on the human Akt2, coupled to KLH |
| Format | Liquid |
| Description |
Protein kinase B or Akt (PKB/Akt) is a serine/threonine kinase, which in mammals comprises three highly homologous members known as PKB alpha (Akt1), PKB beta (Akt2) and PKB gamma (Akt3). PKB/Akt is a growth-factor-regulated protein kinase which contains a Pleckstrin Homology (PH) domain which might be important for dimerization of the kinase. Binding of phosphoinositide 3-OH kinase products to the pleckstrin homology domain results in translocation of PKB/Akt to the plasma membrane where it is activated by phosphorylation by upstream kinases including the phosphoinoside-dependent kinase 1 (PDK1) and PDK2 (1-3). Myelin basic protein and histone H2B are in vitro substrates for PKB, while glycogen synthase kinase-3 has been implicated as a physiological target (4). Key roles for this enzyme can be found in cellular processes such as glucose metabolism, cell proliferation, apoptosis, transcription and cell migration (1-3). Synonyms: AKT2, PKB, PKB beta, PRKBB, protein kinase Akt2, RAC BETA |
| Specificity | Detects a ~65kDa protein, corresponding to the molecular mass of Akt2 PKB beta on SDS-PAGE immunoblots. Does not react with PKBa (Akt1) or PKBb (Akt3). Species cross-reactivity: Human, Mouse, Rat, Bovine, Chicken, Dog, Guinea pig, Hamster, Monkey, Pig, Rabbit, Sheep, Xenopus. |
Application Details
| Application Notes | 1:3000 dilution of SPC-148 was sufficient for detection of PKB |
| Concentration | 0.25mg/mL |
| Buffer | TBS, 50% glycerol, 0.09% sodium azide |
| Storage | -20 °C |
| Storage Shipping Temp Max | Blue Ice or 4 °C |
| Research Area | Cell Signaling |
| Restrictions | For Research Use only |
Publications
| Publications |
Downward: "Mechanisms and consequences of activation of protein kinase B/Akt." in: Current opinion in cell biology, Vol. 10, Issue 2, pp. 262-7, 1998 (PubMed).
Brazil, Hemmings: "Ten years of protein kinase B signalling: a hard Akt to follow." in: Trends in biochemical sciences, Vol. 26, Issue 11, pp. 657-64, 2001 (PubMed). Nicholson, Anderson: "The protein kinase B/Akt signalling pathway in human malignancy." in: Cellular signalling, Vol. 14, Issue 5, pp. 381-95, 2002 (PubMed). |
Alternatives
Alternatives for antigen "V-Akt Murine Thymoma Viral Oncogene Homolog 2 (AKT2)", type "Antibodies"




Alternatives