DNA Damage antibody

Antigen: DNA Damage

Clonality: Monoclonal (15A3)

Host: Mouse

Application: ELISA, Immunohistochemistry (IHC)

Catalog no.: ABIN361744

Additional Information

Immunogen: 8-hydroxy-guanosine-BSA and

Format: Protein G purified

Isotype: IgG2a  (Matching secondary antibodies)

Clone: 15A3

Description: DNA or RNA damage is due to environmental factors and normal metabolic processes inside the cell, that then hinder the ability of the cell to carry out its functions. There are four main types of DNA due to endogenous cellular processes and they are oxidation, alkylation, hydrolysis and mismatch of the bases. During the oxidation of bases, highly reactive chemical entities collectively known as RONS, occurs. RONS stands for reactive oxygen and nitrogen species and includes nitric oxide, superoxide, hydroxyl radical, hydrogen peroxide and peroxynitrite. Numerous studies have shown that RONS causes a variety of issues including DNA damage (1). 8-hydroxyguanine, 8-hydroxy-2

Specificity: Recognizes markers of oxidative damage to DNA (8-hydroxy-2

Application Details

Application Notes: See assay instructions below.

Concentration: 0.65mg/ml

Buffer: Protein G-purified antibody in PBS, in 50% glycerol, 0.1% sodium azide.

Storage: -20°C, 1 year+, shipped on cold packs or ambient

Restrictions: For Research Use only

Images

DNARNA Damage (15A3), ischemic rat brain tissue. Courtesy of Dr. Yi Yang, U. New Mexico